ID   YDGT_SALTI              Reviewed;          71 AA.
AC   Q8XGJ8; Q7AMY0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Transcription modulator YdgT;
DE   AltName: Full=H-NS/StpA-binding protein 2;
DE   AltName: Full=OriC-binding nucleoid-associated protein;
GN   Name=ydgT; Synonyms=cnu; OrderedLocusNames=STY1661, t1329;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
CC   -!- FUNCTION: Binds to H-NS and modified the range of genes it silences; H-
CC       NS alonge silences core gene while the H-NS-Hha complex (and presumably
CC       also H-NS-YdgT) silences genes acquired by horizontal gene transfer.
CC       Plays a role silencing virulence factors in the absence of factors that
CC       induce pathogenicity (By similarity). The complex formed with H-NS
CC       binds to the specific 26-bp cnb site in the origin of replication oriC
CC       (By similarity). {ECO:0000250|UniProtKB:A0A0H3NGF1,
CC       ECO:0000250|UniProtKB:P64467}.
CC   -!- SUBUNIT: Forms complexes with both H-NS and StpA.
CC       {ECO:0000250|UniProtKB:Q7CQK5}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
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DR   EMBL; AE014613; AAO68979.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD01906.1; -; Genomic_DNA.
DR   RefSeq; NP_456069.1; NC_003198.1.
DR   RefSeq; WP_000217946.1; NZ_WSUR01000011.1.
DR   AlphaFoldDB; Q8XGJ8; -.
DR   SMR; Q8XGJ8; -.
DR   STRING; 220341.16502748; -.
DR   EnsemblBacteria; AAO68979; AAO68979; t1329.
DR   GeneID; 66755902; -.
DR   KEGG; stt:t1329; -.
DR   KEGG; sty:STY1661; -.
DR   PATRIC; fig|220341.7.peg.1671; -.
DR   eggNOG; ENOG5032S5U; Bacteria.
DR   HOGENOM; CLU_190629_0_0_6; -.
DR   OMA; PKSVWHF; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   InterPro; IPR036666; HHA_sf.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..71
FT                   /note="Transcription modulator YdgT"
FT                   /id="PRO_0000201737"
FT   SITE            44
FT                   /note="Interacts with H-NS"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8381 MW;  37948CE3814FADA8 CRC64;
     MTVQDYLLKF RKISSLESLE KLFDHLNYTL TDDMDIVNMY RAADHRRAEL VSGGRLFDVG
     QVPQSVWRYV Q