ID   YDGT_SALTS              Reviewed;          76 AA.
AC   A0A0H3NGF1;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Transcription modulator YdgT;
DE   AltName: Full=H-NS/StpA-binding protein 2;
DE   AltName: Full=OriC-binding nucleoid-associated protein;
GN   Name=ydgT; Synonyms=cnu; OrderedLocusNames=SL1344_1393;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SL1344;
RX   PubMed=17307861; DOI=10.1128/jb.00002-07;
RA   Silphaduang U., Mascarenhas M., Karmali M., Coombes B.K.;
RT   "Repression of intracellular virulence factors in Salmonella by the Hha and
RT   YdgT nucleoid-associated proteins.";
RL   J. Bacteriol. 189:3669-3673(2007).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SL1344 / SV5015;
RX   PubMed=19521501; DOI=10.1371/journal.pgen.1000513;
RA   Banos R.C., Vivero A., Aznar S., Garcia J., Pons M., Madrid C., Juarez A.;
RT   "Differential regulation of horizontally acquired and core genome genes by
RT   the bacterial modulator H-NS.";
RL   PLoS Genet. 5:E1000513-E1000513(2009).
CC   -!- FUNCTION: Binds to H-NS and modifies the range of genes it silences; H-
CC       NS alone silences 'core' genes while the H-NS-Hha complex (and
CC       presumably also H-NS-YdgT) silences genes acquired by horizontal gene
CC       transfer (PubMed:19521501). Plays a role silencing virulence factors in
CC       the absence of factors that induce pathogenicity (PubMed:17307861).
CC       {ECO:0000305|PubMed:19521501}.
CC   -!- DISRUPTION PHENOTYPE: No effect on expression of pathogenicity island 2
CC       (SPI-2) which is usually repressed in culture; derepression of SPI-2 in
CC       double hha-ydgT deletions (PubMed:17307861). Double hha-ydgT deletion
CC       mutants lead to deregulation of many genes at least 2-fold, most of
CC       which are also deregulated in an hns deletion, suggesting there are a
CC       large number of hns-regulated genes whose expression is also modulated
CC       by Hha and/or YdgT (PubMed:19521501). Upon infection of C57BL/6 mice a
CC       single hha mutant has 10-100-fold reduced virulence compared to wild-
CC       type, while a double hha-ydgT deletion is 6 orders of magnitude less
CC       virulent (PubMed:17307861). {ECO:0000269|PubMed:17307861,
CC       ECO:0000269|PubMed:19521501}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
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DR   EMBL; FQ312003; CBW17489.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H3NGF1; -.
DR   SMR; A0A0H3NGF1; -.
DR   EnsemblBacteria; CBW17489; CBW17489; SL1344_1393.
DR   KEGG; sey:SL1344_1393; -.
DR   PATRIC; fig|216597.6.peg.1547; -.
DR   HOGENOM; CLU_190629_0_0_6; -.
DR   OMA; PKSVWHF; -.
DR   Proteomes; UP000008962; Chromosome.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   InterPro; IPR036666; HHA_sf.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   3: Inferred from homology;
KW   Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..76
FT                   /note="Transcription modulator YdgT"
FT                   /id="PRO_0000436900"
SQ   SEQUENCE   76 AA;  9031 MW;  2BBFFB84A84FA7E1 CRC64;
     MDQLYMTVQD YLLKFRKISS LESLEKLFDH LNYTLTDDMD IVNMYRAADH RRAELVSGGR
     LFDVGQVPQS VWRYVQ