ID   YDGT_SALTY              Reviewed;          71 AA.
AC   Q7CQK5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transcription modulator YdgT;
DE   AltName: Full=H-NS/StpA-binding protein 2;
DE   AltName: Full=OriC-binding nucleoid-associated protein;
GN   Name=ydgT; Synonyms=cnu; OrderedLocusNames=STM1461;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   SUBUNIT.
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=23515315; DOI=10.1074/jbc.m113.455378;
RA   Ali S.S., Whitney J.C., Stevenson J., Robinson H., Howell P.L.,
RA   Navarre W.W.;
RT   "Structural insights into the regulation of foreign genes in Salmonella by
RT   the Hha/H-NS complex.";
RL   J. Biol. Chem. 288:13356-13369(2013).
CC   -!- FUNCTION: Binds to H-NS and modified the range of genes it silences; H-
CC       NS alonge silences core gene while the H-NS-Hha complex (and presumably
CC       also H-NS-YdgT) silences genes acquired by horizontal gene transfer.
CC       Plays a role silencing virulence factors in the absence of factors that
CC       induce pathogenicity (By similarity). The complex formed with H-NS
CC       binds to the specific 26-bp cnb site in the origin of replication oriC
CC       (By similarity). {ECO:0000250|UniProtKB:A0A0H3NGF1,
CC       ECO:0000250|UniProtKB:P64467}.
CC   -!- SUBUNIT: Forms complexes with both H-NS (PubMed:23515315) and StpA (By
CC       similarity). {ECO:0000250|UniProtKB:P64467,
CC       ECO:0000269|PubMed:23515315}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL20383.1; -; Genomic_DNA.
DR   RefSeq; NP_460424.3; NC_003197.2.
DR   RefSeq; WP_000217946.1; NC_003197.2.
DR   AlphaFoldDB; Q7CQK5; -.
DR   SMR; Q7CQK5; -.
DR   STRING; 99287.STM1461; -.
DR   PaxDb; Q7CQK5; -.
DR   EnsemblBacteria; AAL20383; AAL20383; STM1461.
DR   GeneID; 1252979; -.
DR   GeneID; 66755902; -.
DR   KEGG; stm:STM1461; -.
DR   PATRIC; fig|99287.12.peg.1544; -.
DR   HOGENOM; CLU_190629_0_0_6; -.
DR   PhylomeDB; Q7CQK5; -.
DR   BioCyc; SENT99287:STM1461-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   InterPro; IPR036666; HHA_sf.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome.
FT   CHAIN           1..71
FT                   /note="Transcription modulator YdgT"
FT                   /id="PRO_0000201738"
FT   SITE            44
FT                   /note="Interacts with H-NS"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8381 MW;  37948CE3814FADA8 CRC64;
     MTVQDYLLKF RKISSLESLE KLFDHLNYTL TDDMDIVNMY RAADHRRAEL VSGGRLFDVG
     QVPQSVWRYV Q