YDHC_ECOLI
ID YDHC_ECOLI Reviewed; 403 AA.
AC P37597; P76191; P77477;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Inner membrane transport protein YdhC;
GN Name=ydhC; OrderedLocusNames=b1660, JW1652;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / RR28;
RA Eberhardt S.M.R., Richter G., Gimbel W., Werner T., Bacher A.;
RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP SEQUENCE REVISION TO 373.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP IDENTIFICATION.
RA Rudd K.E.;
RL Unpublished observations (FEB-1994).
RN [7]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=X69109; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X69109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U00096; AAT48135.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15426.1; -; Genomic_DNA.
DR PIR; F64923; F64923.
DR RefSeq; WP_001182347.1; NZ_LN832404.1.
DR RefSeq; YP_025306.1; NC_000913.3.
DR AlphaFoldDB; P37597; -.
DR SMR; P37597; -.
DR BioGRID; 4261211; 154.
DR STRING; 511145.b1660; -.
DR TCDB; 2.A.1.2.62; the major facilitator superfamily (mfs).
DR PaxDb; P37597; -.
DR PRIDE; P37597; -.
DR EnsemblBacteria; AAT48135; AAT48135; b1660.
DR EnsemblBacteria; BAA15426; BAA15426; BAA15426.
DR GeneID; 946077; -.
DR KEGG; ecj:JW1652; -.
DR KEGG; eco:b1660; -.
DR PATRIC; fig|1411691.4.peg.597; -.
DR EchoBASE; EB2062; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_47_1_6; -.
DR InParanoid; P37597; -.
DR OMA; FNIICVV; -.
DR PhylomeDB; P37597; -.
DR BioCyc; EcoCyc:YDHC-MON; -.
DR PRO; PR:P37597; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IBA:GO_Central.
DR InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..403
FT /note="Inner membrane transport protein YdhC"
FT /id="PRO_0000173401"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..41
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..94
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..159
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..237
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..298
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 383..403
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 35
FT /note="D -> E (in Ref. 1; X69109)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="A -> T (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="G -> V (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="L -> M (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="L -> I (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="I -> K (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 210..212
FT /note="LIY -> MKH (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="Y -> N (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="A -> P (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 291..305
FT /note="ISHVSLVEILIPFCV -> NNAXVS (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 335
FT /note="L -> M (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 384..403
FT /note="CEEVGCQNHGNAEVAHSESH -> RIIDSRFFLRDFSQSPKSVYAVLRF
FT (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 403 AA; 43367 MW; 3A046AA46D4781B8 CRC64;
MQPGKRFLVW LAGLSVLGFL ATDMYLPAFA AIQADLQTPA SAVSASLSLF LAGFAAAQLL
WGPLSDRYGR KPVLLIGLTI FALGSLGMLW VENAATLLVL RFVQAVGVCA AAVIWQALVT
DYYPSQKVNR IFAAIMPLVG LSPALAPLLG SWLLVHFSWQ AIFATLFAIT VVLILPIFWL
KPTTKARNNS QDGLTFTDLL RSKTYRGNVL IYAACSASFF AWLTGSPFIL SEMGYSPAVI
GLSYVPQTIA FLIGGYGCRA ALQKWQGKQL LPWLLVLFAV SVIATWAAGF ISHVSLVEIL
IPFCVMAIAN GAIYPIVVAQ ALRPFPHATG RAAALQNTLQ LGLCFLASLV VSWLISISTP
LLTTTSVMLS TVVLVALGYM MQRCEEVGCQ NHGNAEVAHS ESH
