ID   YDHV_ECOLI              Reviewed;         700 AA.
AC   P76192; P71277; Q2MB58;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Uncharacterized oxidoreductase YdhV;
DE            EC=1.-.-.-;
GN   Name=ydhV; OrderedLocusNames=b1673, JW5272;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9023191; DOI=10.1128/jb.179.4.1105-1111.1997;
RA   Hensel M., Shea J.E., Baeumler A.J., Gleeson C., Blattner F.R.,
RA   Holden D.W.;
RT   "Analysis of the boundaries of Salmonella pathogenicity island 2 and the
RT   corresponding chromosomal region of Escherichia coli K-12.";
RL   J. Bacteriol. 179:1105-1111(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   INDUCTION.
RC   STRAIN=K12;
RX   PubMed=18227264; DOI=10.1099/mic.0.2007/012146-0;
RA   Partridge J.D., Browning D.F., Xu M., Newnham L.J., Scott C., Roberts R.E.,
RA   Poole R.K., Green J.;
RT   "Characterization of the Escherichia coli K-12 ydhYVWXUT operon: regulation
RT   by FNR, NarL and NarP.";
RL   Microbiology 154:608-618(2008).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence={ECO:0000250};
CC       Name=tungstopterin; Xref=ChEBI:CHEBI:30402; Evidence={ECO:0000250};
CC       Note=Binds 1 Mo-molybdopterin (Mo-MPT) or 1 tungstopterin cofactor per
CC       subunit. {ECO:0000250};
CC   -!- INDUCTION: Up-regulated by the oxygen-responsive transcription factor
CC       FNR under anaerobic conditions. Repressed in the presence of nitrate or
CC       nitrite via the two-component systems NarXL and NarPQ, respectively.
CC       {ECO:0000269|PubMed:18227264}.
CC   -!- SIMILARITY: Belongs to the AOR/FOR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB47949.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U68703; AAB47949.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC74743.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76498.1; -; Genomic_DNA.
DR   PIR; A64925; A64925.
DR   RefSeq; NP_416188.1; NC_000913.3.
DR   RefSeq; WP_001273527.1; NZ_SSZK01000001.1.
DR   AlphaFoldDB; P76192; -.
DR   SMR; P76192; -.
DR   BioGRID; 4260274; 6.
DR   STRING; 511145.b1673; -.
DR   jPOST; P76192; -.
DR   PaxDb; P76192; -.
DR   PRIDE; P76192; -.
DR   EnsemblBacteria; AAC74743; AAC74743; b1673.
DR   EnsemblBacteria; BAE76498; BAE76498; BAE76498.
DR   GeneID; 948756; -.
DR   KEGG; ecj:JW5272; -.
DR   KEGG; eco:b1673; -.
DR   PATRIC; fig|1411691.4.peg.586; -.
DR   EchoBASE; EB3714; -.
DR   eggNOG; COG2414; Bacteria.
DR   HOGENOM; CLU_020364_0_0_6; -.
DR   InParanoid; P76192; -.
DR   OMA; KAASPVW; -.
DR   PhylomeDB; P76192; -.
DR   BioCyc; EcoCyc:G6901-MON; -.
DR   PRO; PR:P76192; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IDA:EcoCyc.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IDA:EcoCyc.
DR   GO; GO:0016625; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor; IEA:InterPro.
DR   Gene3D; 1.10.569.10; -; 1.
DR   Gene3D; 1.10.599.10; -; 1.
DR   Gene3D; 3.60.9.10; -; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; SSF48310; 1.
DR   SUPFAM; SSF56228; SSF56228; 1.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..700
FT                   /note="Uncharacterized oxidoreductase YdhV"
FT                   /id="PRO_0000168980"
FT   BINDING         307
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250"
FT   BINDING         310
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250"
FT   BINDING         314
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250"
FT   BINDING         558
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   700 AA;  77877 MW;  AA8C1A670C02D804 CRC64;
     MANGWTGNIL RVNLTTGNIT LEDSSKFKSF VGGMGFGYKI MYDEVPPGTK PFDEANKLVF
     ATGPLTGSGA PCSSRVNITS LSTFTKGNLV VDAHMGGFFA AQMKFAGYDV IIIEGKAKSP
     VWLKIKDDKV SLEKADFLWG KGTRATTEEI CRLTSPETCV AAIGQAGENL VPLSGMLNSR
     NHSGGAGTGA IMGSKNLKAI AVEGTKGVNI ADRQEMKRLN DYMMTELIGA NNNHVVPSTP
     QSWAEYSDPK SRWTARKGLF WGAAEGGPIE TGEIPPGNQN TVGFRTYKSV FDLGPAAEKY
     TVKMSGCHSC PIRCMTQMNI PRVKEFGVPS TGGNTCVANF VHTTIFPNGP KDFEDKDDGR
     VIGNLVGLNL FDDYGLWCNY GQLHRDFTYC YSKGVFKRVL PAEEYAEIRW DQLEAGDVNF
     IKDFYYRLAH RVGELSHLAD GSYAIAERWN LGEEYWGYAK NKLWSPFGYP VHHANEASAQ
     VGSIVNCMFN RDCMTHTHIN FIGSGLPLKL QREVAKELFG SEDAYDETKN YTPINDAKIK
     YAKWSLLRVC LHNAVTLCNW VWPMTVSPLK SRNYRGDLAL EAKFFKAITG EEMTQEKLDL
     AAERIFTLHR AYTVKLMQTK DMRNEHDLIC SWVFDKDPQI PVFTEGTDKM DRDDMHASLT
     MFYKEMGWDP QLGCPTRETL QRLGLEDIAA DLAAHNLLPA