ID   YDIV_SALPA              Reviewed;         237 AA.
AC   Q5PH83;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Anti-FlhC(2)FlhD(4) factor YdiV;
GN   Name=ydiV; OrderedLocusNames=SPA1499;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- FUNCTION: Acts as an anti-FlhC(2)FlhD(4) factor by binding to FlhD,
CC       decreasing its ability to bind DNA, and thus negatively regulates
CC       expression of flagellar class II operons, decreasing motility in
CC       nutrient-poor medium. Required for resistance to host phagocyte oxidase
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer,
CC       inhibiting its ability to activate transcription. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YdiV family. {ECO:0000305}.
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DR   EMBL; CP000026; AAV77432.1; -; Genomic_DNA.
DR   RefSeq; WP_000562005.1; NC_006511.1.
DR   AlphaFoldDB; Q5PH83; -.
DR   SMR; Q5PH83; -.
DR   EnsemblBacteria; AAV77432; AAV77432; SPA1499.
DR   KEGG; spt:SPA1499; -.
DR   HOGENOM; CLU_089254_1_1_6; -.
DR   OMA; SFEPFMR; -.
DR   Proteomes; UP000008185; Chromosome.
DR   Gene3D; 3.20.20.450; -; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   Pfam; PF00563; EAL; 1.
DR   SUPFAM; SSF141868; SSF141868; 1.
PE   3: Inferred from homology;
KW   Repressor; Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..237
FT                   /note="Anti-FlhC(2)FlhD(4) factor YdiV"
FT                   /id="PRO_0000346867"
FT   DOMAIN          1..237
FT                   /note="EAL"
SQ   SEQUENCE   237 AA;  26424 MW;  558A591D0B8AC895 CRC64;
     MIASLDELYH SELFFLPVMD ENARLVGLEI IATFAAEDGA VRMPTELVAP RLSVEEQYCL
     FVEKLALLET CQHFFIQHKL IAWLNLPPAI SDLLLLDSEL FSRAARFPFL ELAINENYPG
     LNQGKNNETL ANLAMHFPLM LANFGAGEAS TKAIFDGLFK RVMLDKNFIQ QRAEMISFEP
     FMHAIVAQIS SSCESLMIAG IDTEAMFARA APLGFSAFQG GLWPPVPVSQ LIKLVQR