ID   YDIV_SALTI              Reviewed;         237 AA.
AC   Q8Z6I7; Q7CA76;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Anti-FlhC(2)FlhD(4) factor YdiV;
GN   Name=ydiV; OrderedLocusNames=STY1766, t1225;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Acts as an anti-FlhC(2)FlhD(4) factor by binding to FlhD,
CC       decreasing its ability to bind DNA, and thus negatively regulates
CC       expression of flagellar class II operons, decreasing motility in
CC       nutrient-poor medium. Required for resistance to host phagocyte oxidase
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer,
CC       inhibiting its ability to activate transcription. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YdiV family. {ECO:0000305}.
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DR   EMBL; AE014613; AAO68880.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD02008.1; -; Genomic_DNA.
DR   RefSeq; NP_456167.1; NC_003198.1.
DR   RefSeq; WP_000561998.1; NZ_WSUR01000011.1.
DR   AlphaFoldDB; Q8Z6I7; -.
DR   SMR; Q8Z6I7; -.
DR   STRING; 220341.16502846; -.
DR   EnsemblBacteria; AAO68880; AAO68880; t1225.
DR   KEGG; stt:t1225; -.
DR   KEGG; sty:STY1766; -.
DR   PATRIC; fig|220341.7.peg.1778; -.
DR   eggNOG; COG2200; Bacteria.
DR   HOGENOM; CLU_089254_1_1_6; -.
DR   OMA; SFEPFMR; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   Gene3D; 3.20.20.450; -; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   Pfam; PF00563; EAL; 1.
DR   SUPFAM; SSF141868; SSF141868; 1.
PE   3: Inferred from homology;
KW   Repressor; Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..237
FT                   /note="Anti-FlhC(2)FlhD(4) factor YdiV"
FT                   /id="PRO_0000346869"
FT   DOMAIN          1..237
FT                   /note="EAL"
SQ   SEQUENCE   237 AA;  26426 MW;  638213CE47E10E21 CRC64;
     MIASLDELYH SELFFLPVMD ENARLVGLEI IATFAAEDGA VRMPTELVAP RLSVEEQYCL
     FVEKLALLET CQHFFIQHKL IAWLNLPPAI SDLLLLDSEL FSRAARFPFF EVAINENYPG
     LNQGKNNETL ANLAMHFPLI LANFGAGEAS TKAIFDGLFK RVMLDKNFIQ QRAEMISFEP
     FMHAIVAQIS SSCESLMIAG IDTEAMFARA APLGFSAFQG GLWPPVPVSQ LIKLVQR