YDJC_HUMAN
ID YDJC_HUMAN Reviewed; 323 AA.
AC A8MPS7; Q2YDT4; Q4V9R7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Carbohydrate deacetylase {ECO:0000250|UniProtKB:Q53WD3};
DE EC=3.5.1.- {ECO:0000250|UniProtKB:Q53WD3};
GN Name=YDJC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Probably catalyzes the deacetylation of acetylated
CC carbohydrates an important step in the degradation of oligosaccharides.
CC {ECO:0000250|UniProtKB:Q53WD3}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q53WD3};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A8MPS7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MPS7-2; Sequence=VSP_032786, VSP_032787;
CC Name=3;
CC IsoId=A8MPS7-3; Sequence=VSP_032784, VSP_032785;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the YdjC deacetylase family. {ECO:0000305}.
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DR EMBL; AP000553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW59461.1; -; Genomic_DNA.
DR EMBL; CH471095; EAW59463.1; -; Genomic_DNA.
DR EMBL; BC096754; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC110075; AAI10076.1; -; mRNA.
DR EMBL; BC133043; AAI33044.1; -; mRNA.
DR EMBL; BC133047; AAI33048.1; -; mRNA.
DR CCDS; CCDS33613.1; -. [A8MPS7-1]
DR RefSeq; NP_001017964.1; NM_001017964.1. [A8MPS7-1]
DR RefSeq; XP_011528208.1; XM_011529906.2.
DR AlphaFoldDB; A8MPS7; -.
DR SMR; A8MPS7; -.
DR BioGRID; 127272; 12.
DR IntAct; A8MPS7; 3.
DR STRING; 9606.ENSP00000292778; -.
DR iPTMnet; A8MPS7; -.
DR PhosphoSitePlus; A8MPS7; -.
DR BioMuta; YDJC; -.
DR EPD; A8MPS7; -.
DR jPOST; A8MPS7; -.
DR MassIVE; A8MPS7; -.
DR MaxQB; A8MPS7; -.
DR PaxDb; A8MPS7; -.
DR PeptideAtlas; A8MPS7; -.
DR PRIDE; A8MPS7; -.
DR ProteomicsDB; 1911; -. [A8MPS7-1]
DR ProteomicsDB; 1912; -. [A8MPS7-2]
DR ProteomicsDB; 1913; -. [A8MPS7-3]
DR Antibodypedia; 54203; 65 antibodies from 11 providers.
DR DNASU; 150223; -.
DR Ensembl; ENST00000292778.11; ENSP00000292778.6; ENSG00000161179.14. [A8MPS7-1]
DR Ensembl; ENST00000398873.4; ENSP00000381847.3; ENSG00000161179.14. [A8MPS7-2]
DR Ensembl; ENST00000415762.6; ENSP00000402481.2; ENSG00000161179.14. [A8MPS7-3]
DR GeneID; 150223; -.
DR KEGG; hsa:150223; -.
DR MANE-Select; ENST00000292778.11; ENSP00000292778.6; NM_001017964.2; NP_001017964.1.
DR UCSC; uc002zvb.4; human. [A8MPS7-1]
DR CTD; 150223; -.
DR DisGeNET; 150223; -.
DR GeneCards; YDJC; -.
DR HGNC; HGNC:27158; YDJC.
DR HPA; ENSG00000161179; Low tissue specificity.
DR MIM; 619770; gene.
DR neXtProt; NX_A8MPS7; -.
DR OpenTargets; ENSG00000161179; -.
DR PharmGKB; PA162409362; -.
DR VEuPathDB; HostDB:ENSG00000161179; -.
DR eggNOG; ENOG502RYFJ; Eukaryota.
DR GeneTree; ENSGT00390000002575; -.
DR HOGENOM; CLU_064244_1_0_1; -.
DR InParanoid; A8MPS7; -.
DR OMA; HPQEGGC; -.
DR OrthoDB; 845079at2759; -.
DR PhylomeDB; A8MPS7; -.
DR TreeFam; TF329340; -.
DR BRENDA; 3.5.1.105; 2681.
DR PathwayCommons; A8MPS7; -.
DR SignaLink; A8MPS7; -.
DR BioGRID-ORCS; 150223; 23 hits in 1083 CRISPR screens.
DR ChiTaRS; YDJC; human.
DR GenomeRNAi; 150223; -.
DR Pharos; A8MPS7; Tbio.
DR PRO; PR:A8MPS7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; A8MPS7; protein.
DR Bgee; ENSG00000161179; Expressed in granulocyte and 117 other tissues.
DR ExpressionAtlas; A8MPS7; baseline and differential.
DR Genevisible; A8MPS7; HS.
DR GO; GO:0019213; F:deacetylase activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR006879; YdjC-like.
DR PANTHER; PTHR31609; PTHR31609; 1.
DR Pfam; PF04794; YdjC; 1.
DR SUPFAM; SSF88713; SSF88713; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Carbohydrate metabolism; Hydrolase; Magnesium;
KW Metal-binding; Reference proteome.
FT CHAIN 1..323
FT /note="Carbohydrate deacetylase"
FT /id="PRO_0000328774"
FT ACT_SITE 13
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q53WD3"
FT BINDING 14
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250|UniProtKB:Q53WD3"
FT BINDING 134
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250|UniProtKB:Q53WD3"
FT VAR_SEQ 111..136
FT /note="EELEAQLSCFRELLGRAPTHADGHQH -> SRSYRRMLARTPRAPPGGCGRS
FT SRPN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032784"
FT VAR_SEQ 137..323
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032785"
FT VAR_SEQ 143..149
FT /note="VCQVFAE -> GQTPSWA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032786"
FT VAR_SEQ 150..323
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032787"
FT VARIANT 263
FT /note="A -> T (in dbSNP:rs2298428)"
FT /id="VAR_042519"
SQ SEQUENCE 323 AA; 34466 MW; CAD754CCCC4D99A4 CRC64;
MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA ELARRHSIPT
GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA AGDVDLPQVR EELEAQLSCF
RELLGRAPTH ADGHQHVHVL PGVCQVFAEA LQAYGVRFTR LPLERGVGGC TWLEAPARAF
ACAVERDARA AVGPFSRHGL RWTDAFVGLS TCGRHMSAHR VSGALARVLE GTLAGHTLTA
ELMAHPGYPS VPPTGGCGEG PDAFSCSWER LHELRVLTAP TLRAQLAQDG VQLCALDDLD
SKRPGEEVPC EPTLEPFLEP SLL
