YDK2_SCHPO
ID YDK2_SCHPO Reviewed; 757 AA.
AC P87109;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable phospholipase C20G8.02, mitochondrial;
DE Flags: Precursor;
GN ORFNames=SPAC20G8.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Probable phospholipase that hydrolyzes phosphatidic acid.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the PA-PLA1 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB08596.1; -; Genomic_DNA.
DR PIR; T38124; T38124.
DR RefSeq; NP_593319.1; NM_001018750.2.
DR AlphaFoldDB; P87109; -.
DR STRING; 4896.SPAC20G8.02.1; -.
DR iPTMnet; P87109; -.
DR MaxQB; P87109; -.
DR PaxDb; P87109; -.
DR PRIDE; P87109; -.
DR EnsemblFungi; SPAC20G8.02.1; SPAC20G8.02.1:pep; SPAC20G8.02.
DR GeneID; 2541976; -.
DR KEGG; spo:SPAC20G8.02; -.
DR PomBase; SPAC20G8.02; -.
DR VEuPathDB; FungiDB:SPAC20G8.02; -.
DR eggNOG; KOG2308; Eukaryota.
DR HOGENOM; CLU_007365_1_0_1; -.
DR InParanoid; P87109; -.
DR OMA; NFTHSIN; -.
DR PhylomeDB; P87109; -.
DR Reactome; R-SPO-1483166; Synthesis of PA.
DR Reactome; R-SPO-1483226; Synthesis of PI.
DR Reactome; R-SPO-204005; COPII-mediated vesicle transport.
DR PRO; PR:P87109; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; ISM:PomBase.
DR GO; GO:0004620; F:phospholipase activity; ISS:PomBase.
DR GO; GO:0044242; P:cellular lipid catabolic process; IC:PomBase.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004177; DDHD_dom.
DR Pfam; PF02862; DDHD; 2.
DR SMART; SM01127; DDHD; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS51043; DDHD; 1.
DR PROSITE; PS00120; LIPASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase; Lipid degradation; Lipid metabolism; Mitochondrion;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 14..757
FT /note="Probable phospholipase C20G8.02, mitochondrial"
FT /id="PRO_0000316026"
FT DOMAIN 547..757
FT /note="DDHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00378"
FT REGION 289..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 524
FT /evidence="ECO:0000250"
SQ SEQUENCE 757 AA; 85691 MW; 357C7F4F7B7A258D CRC64;
MILYIVLPFY VRTKPYSILP SYSSLQWITN AWCSLPSIYI LCHCSKHQEE ITILALKPLI
AMNNSEEWPL KHVQPPKLSF RHLLSRSVTD APSLRVRWFY AVDRPLRKSR TGPTEIKKAK
NFLPFSAEDS EHIEKSYLKA VENDGQSEPV NVNEDYLYSV NVVSRELSPI YWDGPVYRIL
RGTWFFSRGD KLYPCEENLA TQVEEGYLNS CPYREFSNEK DSAAAQSKTW ALLGRYTGGF
VQYTGSRNAR LVYDDFYRNV SVKIMNRFSP ASFHRSDKLV RGYELDMLES NSKPSTPVPT
EELTSTTLLN DSSDPSDNFT PSNTESTIDL PSATDASHLM SRPDREVNHL ILCCHGIGQK
MGERVETVSF VKDISNFRKT LKKTFNSSPD LQAVYPKLKG GGNGVQCLPL LWRQDIRFGM
ARDLDSSFAD DDDDDDESLN MSRDLALDDL EDDSIPTLDN INIPTVTGLR NIISDVLLDV
LLYCQPNYRD KILAAVVKRL NRLYNLYKKN VPSFNGHVSL LGHSLGALIL FDIIRYQGNI
KYSKLQLDFP VANFFALGSP LGLFQMLNGK KIAGPIPKTN LTRSLSYSEQ SFDSGVSILS
CQNFYNIFHP TDPISYRVEP LVVKQMARLK PQKISHFRPH QDLSSSGVGH KIAGGALNVL
SGLRSGIANT LILKSLSYAS VFNEATADSH DESQGAENIR DWHIDERMYR LNKTGRIDFM
LQEGALDTSY SYVSAMNAHS EYWKNVDLAH FILTQLL
