YDL6_SCHPO
ID YDL6_SCHPO Reviewed; 743 AA.
AC P87122;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Putative cation exchanger C3A12.06c;
GN ORFNames=SPAC3A12.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Putative cation exchanger. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CAB08751.1; -; Genomic_DNA.
DR PIR; T38674; T38674.
DR RefSeq; NP_593332.1; NM_001018763.2.
DR AlphaFoldDB; P87122; -.
DR BioGRID; 279612; 17.
DR STRING; 4896.SPAC3A12.06c.1; -.
DR iPTMnet; P87122; -.
DR PaxDb; P87122; -.
DR PRIDE; P87122; -.
DR EnsemblFungi; SPAC3A12.06c.1; SPAC3A12.06c.1:pep; SPAC3A12.06c.
DR GeneID; 2543183; -.
DR KEGG; spo:SPAC3A12.06c; -.
DR PomBase; SPAC3A12.06c; -.
DR VEuPathDB; FungiDB:SPAC3A12.06c; -.
DR eggNOG; KOG2399; Eukaryota.
DR HOGENOM; CLU_004979_2_1_1; -.
DR InParanoid; P87122; -.
DR OMA; MNIANEV; -.
DR PhylomeDB; P87122; -.
DR Reactome; R-SPO-425561; Sodium/Calcium exchangers.
DR Reactome; R-SPO-8949215; Mitochondrial calcium ion transport.
DR PRO; PR:P87122; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008324; F:cation transmembrane transporter activity; ISM:PomBase.
DR GO; GO:0098655; P:cation transmembrane transport; ISM:PomBase.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..743
FT /note="Putative cation exchanger C3A12.06c"
FT /id="PRO_0000317130"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 551..571
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 718..738
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 743 AA; 82397 MW; 15B5FD26FACF8BB8 CRC64;
MSKTSCFLKK YRLILLWCIL GIAYILFWTH RISKAFASVS STSDSTVHLF ERGNTLNDSN
DQILLTCNDI KNITPANQCR FAKAYCKGEA SGFFDYVEFY FCTINSLRFP VLSIIVGWLI
FLFITIGISA SDFFSTNLVT ISWLLQLPDS VVGVTFLALG NGSPDILSTF AAVRVNSGGM
AIGELLGSAF FIVAIVAGSV CLIKPFKIPR RHFLRDVAFL TGTILLVIMF VLHDGSLSIW
QSLVMILYYL LYVLFVFFSG SSGVSVVITD ENYLPVSLPV YSPVLNSFDD SDSYSSTDSE
LSEEAFLLPA QASRKTQKIH YINDNDPSNS YSSYQHSHVH DFIHKNNTHS NRVLSQSSGP
IVRPSLLAAL DFRSSNEEQH PGLRSLDPLN IQDGDLTMHP MHIRHSQSDF YPSGINTPVS
GINYPNLGFS ANNSVQSLVS EIFRHPTHTD EDFPLPSPSL SSLLFPTLRN FAKKSWYEKL
MDVLAVPSVL IFTLALPVYQ CPRLAVDPIY HMDVSNCNPS KPTWSRKLRL LQCVFVPFAF
VTFSITGGNR LYIYAASSVF SILCITALYY YTDEEKPPKF LPWVSFIGFV LGIIWISTIA
NEVVGILRAL GVIFNLNESI LGLTVFAAGN SLSDLIADIM IARSGFPEMA MGGVFGGPTL
NILIGIGISS FYSSISNHGN DSVIEIPHSL SITAYFLLAC LLLLLIYVPL NRFRVNRVLG
LLLFILYIVG TSTNIVVELL KDK
