YDU2_SCHPO
ID YDU2_SCHPO Reviewed; 537 AA.
AC O13863;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Uncharacterized kinase C1B1.02c;
DE EC=2.7.1.-;
GN ORFNames=SPAC1B1.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SIMILARITY: Belongs to the NAD kinase family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11081.1; -; Genomic_DNA.
DR PIR; T38015; T38015.
DR RefSeq; NP_594232.1; NM_001019655.2.
DR AlphaFoldDB; O13863; -.
DR SMR; O13863; -.
DR BioGRID; 278991; 3.
DR STRING; 4896.SPAC1B1.02c.1; -.
DR iPTMnet; O13863; -.
DR MaxQB; O13863; -.
DR PaxDb; O13863; -.
DR PRIDE; O13863; -.
DR EnsemblFungi; SPAC1B1.02c.1; SPAC1B1.02c.1:pep; SPAC1B1.02c.
DR GeneID; 2542533; -.
DR KEGG; spo:SPAC1B1.02c; -.
DR PomBase; SPAC1B1.02c; -.
DR VEuPathDB; FungiDB:SPAC1B1.02c; -.
DR eggNOG; KOG2178; Eukaryota.
DR HOGENOM; CLU_008831_1_4_1; -.
DR InParanoid; O13863; -.
DR OMA; LNWNDRK; -.
DR PhylomeDB; O13863; -.
DR Reactome; R-SPO-196807; Nicotinate metabolism.
DR PRO; PR:O13863; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0003951; F:NAD+ kinase activity; ISO:PomBase.
DR GO; GO:0019674; P:NAD metabolic process; ISO:PomBase.
DR GO; GO:0006741; P:NADP biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.30; -; 1.
DR Gene3D; 3.40.50.10330; -; 1.
DR HAMAP; MF_00361; NAD_kinase; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR002504; NADK.
DR Pfam; PF01513; NAD_kinase; 1.
DR SUPFAM; SSF111331; SSF111331; 1.
PE 1: Evidence at protein level;
KW Kinase; NAD; NADP; Phosphoprotein; Reference proteome; Transferase.
FT CHAIN 1..537
FT /note="Uncharacterized kinase C1B1.02c"
FT /id="PRO_0000120718"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 537 AA; 60708 MW; A5B52D41FF6B1953 CRC64;
MEPGSKLSED ETFSQTFNEE EQEDSRNKDI LAFDPSVDNE PLLTKKLSSL SIYSEPSPDE
ASNLQELKFV SSPPSVRVPR SRRNRRNSRV DSEARKRQFD RVKHSVSNSC KLHLSLQGQE
AAQLRSDSLY LEASDKRDLT SLVTRVKELA RKLSAARLAF RFRKVLLICN DNKESIERSV
ELAQWLLDTF SFTPSSSHNN MASSNTQSNT QLSEMESEEK SFNKDVYPND EYTPFTPKNQ
FVIYLEDTLA SLDVVESLSP KKNVRFWTSE LCTQCPNLFD CVITVGDDSA ALRASWLFQD
VVPPVLSFST AKAGFLSILP IAEYTKTLDL IFHRGFTVNL RMRFQCSIMR YVGEHSTHIC
EGQYSVLNEL LIDRGPNPFM ISLDLYVENE YITTLQSDGV CVSTPTGSTA YSVAAGGSLC
HPGIPAILIS AICPHSLSFR PIILPDSMTL RIVVPLDARS NAWCAFDGHH RIELGLGDYI
SISASSFPFP SVIRSKYSKD WFDILRQTLN WNDRKGRQRS SRYKSHVHKT NTSEEQN
