YE077_YEAST
ID YE077_YEAST Reviewed; 1277 AA.
AC Q3E7X8; D3DLH4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Y' element ATP-dependent helicase YEL077C;
DE EC=3.6.4.12;
GN OrderedLocusNames=YEL077C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is
RT induced in survivors defective for telomerase.";
RL J. Biol. Chem. 273:33360-33366(1998).
CC -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- INDUCTION: Induced in absence of telomerase TLC1.
CC {ECO:0000269|PubMed:9837911}.
CC -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC repeat subfamily. {ECO:0000305}.
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DR EMBL; U73806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006939; DAA07578.1; -; Genomic_DNA.
DR RefSeq; NP_010835.1; NM_001184302.1.
DR AlphaFoldDB; Q3E7X8; -.
DR BioGRID; 36654; 24.
DR DIP; DIP-48278N; -.
DR STRING; 4932.YEL077C; -.
DR CarbonylDB; Q3E7X8; -.
DR PaxDb; Q3E7X8; -.
DR PRIDE; Q3E7X8; -.
DR EnsemblFungi; YEL077C_mRNA; YEL077C; YEL077C.
DR GeneID; 856630; -.
DR KEGG; sce:YEL077C; -.
DR SGD; S000006409; YEL077C.
DR VEuPathDB; FungiDB:YEL077C; -.
DR eggNOG; ENOG502QWCT; Eukaryota.
DR GeneTree; ENSGT00940000153173; -.
DR HOGENOM; CLU_011178_2_0_1; -.
DR BioCyc; YEAST:G3O-30356-MON; -.
DR PRO; PR:Q3E7X8; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; Q3E7X8; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0004386; F:helicase activity; ISS:SGD.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..1277
FT /note="Y' element ATP-dependent helicase YEL077C"
FT /id="PRO_0000268166"
FT DOMAIN 222..399
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 454..605
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 696..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 345..348
FT /note="DEAH box"
FT COMPBIAS 775..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 235..242
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1277 AA; 143092 MW; 430F1585F29AFD27 CRC64;
MTLGNSYDAF NHDPWMDVVG FEDPNQVTNR DISRIVLYSY MFLNTAKGCL VEYATFRQYM
RELPKNAPQK LNFREMRQGL IALGRHCVGS RFETDLYESA TSELMANHSV QTGRNIYGVD
SFSLTSVSGT TATLLQERAS ERWIQWLGLE SDYHCSFSST RNAEDVVAGE AASSDHHQKI
SRVTRKRPRE PKSTNDILVA GQKLFGSSFE FRDLHQLRLC YEIYMADTPS VAVQAPPGYG
KTELFHLPLI ALASKGDVKY VSFLFVPYTV LLANCMIRLG RCGCLNVAPV RNFIEEGYDG
VTDLYVGIYD DLASTNFTDR IAAWENIVEC TFRTNNVKLG YLIVDEFHNF ETEVYRQSQF
GGITNLDFDA FEKAIFLSGT APEAVADAAL QRIGLTGLAK KSMDINELKR SEDLSRGLSS
YPTRMFNLIK EKSEVPLGHV HKIRKKVESQ PEEALKLLLA LFESEPESKA IVVASTTNEV
EELACSWRKY FRVVWIHGKL DAAEKVSRTK EFVTDGNMRV LIGTKLVTEG IDIKQLMMVI
MLDNRLNIIE LIQGVGRLRD GGLCYLLSRK NSWAARNRKG ELPPIKEGCI TEQVREFYGL
ESKKGKKGQH VGCCGSRTDL SADTVELIER MDRLAEKQAT ASMSIVALPS NFQESNSSDR
YRKYCSSDED SNTCIHGSAN ASTNASTNAI TTASTNVRTN ATTNASTNAT TNASTNATTN
SSTNATTTAS TNVRTSATTT ASINVRTSAT TTESTNSSTN ATTTASINVR TSATTTKSIN
SSTNATITES TNSNTNATTT ESTNSKTSAT TTASTNSNTS ATTTESTNSK TSATTTASTN
SNTSATTTES TNSNTSATTT ASTNSSTNAT TTESTNASAK EDANKDGNAE DNRFHPVTDI
NKESYKRKGS QMVLLERKKL KAQFPNTSEN MNVLQFLGFR SDEIKHLFLY GIDIYFCPEG
VFTQYGLCKG CQKMFELCVC WAGQKVSYRR MAWEALAVER MLRNDEEYKE YLEDIEPYHG
DPVGYLKYFS VKRREIYSQI QRNYAWYLAI TRRRETISVL DSTRGKQGSQ VFRMSGRQIK
ELYYKVWSNL RESKTEVLQY FLNWDEKKCQ EEWEAKDDTV FVEALEKVGV FQRLRSMTSA
GLQGPQYVKL QFSRHHRQLR SRYELSLGMH LRDQIALGVT PSKVPHWTAF LSMLIGLFYN
KTFRQKLEYL LEQISEVWLL PHWLDLANVE VLAADNTKVP LYMLMVAVHK ELDSDDVPDG
RFDIILLCRD SSREVGE
