ID   YE25_CAEEL              Reviewed;         507 AA.
AC   Q20593; Q20592;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Glycosyltransferase family 92 protein F49C12.5;
DE            EC=2.4.1.- {ECO:0000305};
GN   ORFNames=F49C12.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q20593-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q20593-2; Sequence=VSP_002448;
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 92 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z68227; CAA92518.1; -; Genomic_DNA.
DR   EMBL; Z68227; CAA92519.1; -; Genomic_DNA.
DR   PIR; T22419; T22419.
DR   PIR; T22420; T22420.
DR   RefSeq; NP_501627.1; NM_069226.1. [Q20593-1]
DR   AlphaFoldDB; Q20593; -.
DR   PaxDb; Q20593; -.
DR   EnsemblMetazoa; F49C12.5.1; F49C12.5.1; WBGene00009875. [Q20593-1]
DR   GeneID; 186028; -.
DR   KEGG; cel:CELE_F49C12.5; -.
DR   UCSC; F49C12.5a; c. elegans. [Q20593-1]
DR   CTD; 186028; -.
DR   WormBase; F49C12.5; CE05896; WBGene00009875; -. [Q20593-1]
DR   eggNOG; KOG4735; Eukaryota.
DR   GeneTree; ENSGT00970000195836; -.
DR   HOGENOM; CLU_028496_1_0_1; -.
DR   InParanoid; Q20593; -.
DR   OMA; REYENDG; -.
DR   OrthoDB; 959479at2759; -.
DR   PhylomeDB; Q20593; -.
DR   PRO; PR:Q20593; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008166; Glyco_transf_92.
DR   Pfam; PF01697; Glyco_transf_92; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Glycosyltransferase; Membrane; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..507
FT                   /note="Glycosyltransferase family 92 protein F49C12.5"
FT                   /id="PRO_0000065354"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          155..444
FT                   /note="GT92"
FT   VAR_SEQ         33..60
FT                   /note="KGTSPIPVKERPLKAFITSAYYYSSSKS -> N (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002448"
SQ   SEQUENCE   507 AA;  58556 MW;  C412AE0C5736AD97 CRC64;
     MRPIHRRPEK VAILVTAVLF AITIIFSVFK NGKGTSPIPV KERPLKAFIT SAYYYSSSKS
     LGKNALALVM SINLVKSPNE LAQHPNPPEL VISAENDTTS IMVKTPYSRV TPHDVCQIIT
     VFATVQLLPN VKSIKMVSGN ELTEIPFSKP SSLKRDVVVC TSPLFVSEQW QNFLFAVHIY
     KKFDAHMNLY LVSSITSFYE LMKEYEKEGY MTIQPWVSVK YPEVSKIIAD SYDQIEFRNQ
     AAAQTDCLLQ FKESARFITF LDLDDVLIPK LAPTYAEEFQ KLMVTKKRSS FIFYHKENYN
     VAATRYGSKF SLKNMFNSME CQNNRETGKI VVNPKHLNFT WIHYPPISPE ELAKHEVTEN
     VITHLKTIVW VDEEPDGENQ KIIEPLYYDN STDTILSRQQ IKELETDLEN MMMKPNIQKI
     FAQLPDIHYY TDLVVNCYND RYYKYHYSGR ISEITCPGPQ LCEYHQHPNI TCMRVNATYH
     SMKTLSPITY YYANDPHFTS EMGCYAH