YE66_SCHPO
ID YE66_SCHPO Reviewed; 376 AA.
AC O14252;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Putative oxidoreductase C6G10.06;
DE EC=1.-.-.-;
GN ORFNames=SPAC6G10.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP INDUCTION.
RX PubMed=12161753; DOI=10.1038/ng951;
RA Mata J., Lyne R., Burns G., Baehler J.;
RT "The transcriptional program of meiosis and sporulation in fission yeast.";
RL Nat. Genet. 32:143-147(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Putative oxidoreductase that negatively regulates the
CC retrieval of cargo from late endosomes to the Golgi. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC -!- INDUCTION: Expression shows a peak that coincides with the meiotic
CC divisions. {ECO:0000269|PubMed:12161753}.
CC -!- SIMILARITY: Belongs to the TDA3 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11292.1; -; Genomic_DNA.
DR PIR; T39056; T39056.
DR RefSeq; NP_594103.1; NM_001019527.1.
DR AlphaFoldDB; O14252; -.
DR SMR; O14252; -.
DR BioGRID; 278846; 17.
DR STRING; 4896.SPAC6G10.06.1; -.
DR SwissPalm; O14252; -.
DR PaxDb; O14252; -.
DR EnsemblFungi; SPAC6G10.06.1; SPAC6G10.06.1:pep; SPAC6G10.06.
DR GeneID; 2542382; -.
DR KEGG; spo:SPAC6G10.06; -.
DR PomBase; SPAC6G10.06; -.
DR VEuPathDB; FungiDB:SPAC6G10.06; -.
DR eggNOG; KOG2852; Eukaryota.
DR HOGENOM; CLU_007884_14_1_1; -.
DR InParanoid; O14252; -.
DR OMA; HANWGIT; -.
DR PhylomeDB; O14252; -.
DR PRO; PR:O14252; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISO:PomBase.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEP:PomBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:PomBase.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Oxidoreductase; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..376
FT /note="Putative oxidoreductase C6G10.06"
FT /id="PRO_0000353796"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 376 AA; 41767 MW; FF67EF78BEA4ABAC CRC64;
MSATSREGNK TKIGIVGGGI IGICTAFYLT EEQEYKKGEL DIFIFESKEI AGGSSGIDSA
ILTKLCQNEI IQPLSTLALK LYEGLDKKFD GKKNWEYRTA NSWFCKMKWD NTNVAKVPDT
LQWLQRERMQ KCSSIGSGND FAMINPKLFC QFMAKEIEKR GVKFIFGSVK EVSKHHITYV
PKQEAEDTII KAQVHKTLVS AGPWTGYLLP FTGIAGLCIP IIHLSVGNFP VGDSIVVCCL
NTMGNLNICK TTEIFSKNRE QLIFMGTPKF HLLPKDSNRC FFNPFEIIEL KEMTDLVLSE
NTKSNYLDAS FKFLPTSRIT GIPIISTTKS GVFVAAGHAN WGITQAPATG LCMAEMLLGK
EKTSINTDPF HLNLGE
