ID   YE7A_SCHPO              Reviewed;         785 AA.
AC   O14162;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Putative lipase C4A8.10;
DE            EC=3.1.-.-;
GN   ORFNames=SPAC4A8.10;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
CC   -!- SIMILARITY: Belongs to the putative lipase ROG1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB11480.2; -; Genomic_DNA.
DR   PIR; T38780; T38780.
DR   RefSeq; NP_593822.2; NM_001019251.2.
DR   AlphaFoldDB; O14162; -.
DR   BioGRID; 280031; 38.
DR   STRING; 4896.SPAC4A8.10.1; -.
DR   ESTHER; schpo-ye7a; Duf_676.
DR   iPTMnet; O14162; -.
DR   MaxQB; O14162; -.
DR   PaxDb; O14162; -.
DR   PRIDE; O14162; -.
DR   EnsemblFungi; SPAC4A8.10.1; SPAC4A8.10.1:pep; SPAC4A8.10.
DR   PomBase; SPAC4A8.10; -.
DR   VEuPathDB; FungiDB:SPAC4A8.10; -.
DR   eggNOG; KOG4372; Eukaryota.
DR   HOGENOM; CLU_007367_1_0_1; -.
DR   InParanoid; O14162; -.
DR   OMA; CFITADQ; -.
DR   PRO; PR:O14162; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005811; C:lipid droplet; ISO:PomBase.
DR   GO; GO:0047372; F:acylglycerol lipase activity; ISO:PomBase.
DR   GO; GO:0044242; P:cellular lipid catabolic process; ISO:PomBase.
DR   GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007751; DUF676_lipase-like.
DR   InterPro; IPR044294; Lipase-like.
DR   InterPro; IPR016445; Rog1_fam.
DR   PANTHER; PTHR12482; PTHR12482; 1.
DR   Pfam; PF05057; DUF676; 1.
DR   PIRSF; PIRSF005412; UCP005412_abhydr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT   CHAIN           1..785
FT                   /note="Putative lipase C4A8.10"
FT                   /id="PRO_0000116704"
FT   REGION          29..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        390
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   785 AA;  86647 MW;  78A3F50DA59A605C CRC64;
     MNVYVQRDDV GLGQIHRFRI FVQSGGNLHS ATSSTTVPPT VNLNSVTKKE SGSIEDRAGS
     GGMTISSGEN ISKQISENNS STNPKHANSE SSPLLSSDFS SSSKDYHKVG AFTDNTNAIN
     IPEQTRGVSH TSSSPSVGTS FSSINLREVK NPLAGSDSTA PFINSTNSVL WIRVRNREAR
     FRQAAYLQGP FTLCVSVWND QFFDEKNSLL NFDPQVQPST SFWVCVPYSC FSNQQPIYIE
     IASQAIFKDR SINFELAISQ SQHSIRAMSA ADIDTLHAFP ALHVEHQTPE NLWRLPYSSF
     HSKNSHLVVL THGMHSNVGA DMEYLKEKLI ESSKSVKELV VVRGFTGNYC QTEKGVRWLG
     KRLGEWLLDI TGWGSASFPR YSHISVVAHS LGGLVQTYAV GYVHAKTHGA FFQAIHPVFF
     VTLATPWLGV AGEHPSYIGK ALSYGIIGKT GQDLSLTPLN HSIESRPFLV LMSDPSTPFF
     QAVSFFEKRI LFANTTNDYI VPFGTSAMEV SSLGKVEEAE GSDKVMPTHM ENGISPTLKE
     NEQTVQSVGD NAKKIHASSE ESGSSFSKAL KSFVGLFSYS ASKTTDTEIP LVKNEDENAR
     KPTEPNCLGS DELDVSNSSN QFFCSAPKLD PTSTFSGVAQ RVVNTFTNLF IPAVPTDSYF
     FKYHLHKVVV SDNVHDPAAS FSTFDGITEL NNMNNGFLSN EITIAKNWHR LAWRKVAVRL
     DGDAHNTMIV RRRFPNAYGW TVIKHLTEIL FEQNTSTAYM NPISFDETTT AAWLSEIYED
     NSISV