YE8A_SCHPO
ID YE8A_SCHPO Reviewed; 1191 AA.
AC O14306;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Probable inositol polyphosphate 5-phosphatase C9G1.10c;
DE EC=3.1.3.-;
GN ORFNames=SPAC9G1.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB11494.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC Note=Barrier septum. Cell tip. {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11494.2; -; Genomic_DNA.
DR PIR; T39233; T39233.
DR RefSeq; NP_593565.1; NM_001018998.2.
DR AlphaFoldDB; O14306; -.
DR SMR; O14306; -.
DR BioGRID; 278795; 32.
DR IntAct; O14306; 1.
DR STRING; 4896.SPAC9G1.10c.1; -.
DR iPTMnet; O14306; -.
DR MaxQB; O14306; -.
DR PaxDb; O14306; -.
DR PRIDE; O14306; -.
DR EnsemblFungi; SPAC9G1.10c.1; SPAC9G1.10c.1:pep; SPAC9G1.10c.
DR GeneID; 2542329; -.
DR KEGG; spo:SPAC9G1.10c; -.
DR PomBase; SPAC9G1.10c; -.
DR VEuPathDB; FungiDB:SPAC9G1.10c; -.
DR eggNOG; KOG0565; Eukaryota.
DR HOGENOM; CLU_002027_1_0_1; -.
DR InParanoid; O14306; -.
DR OMA; CVFVKHK; -.
DR PhylomeDB; O14306; -.
DR PRO; PR:O14306; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030479; C:actin cortical patch; ISO:PomBase.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; ISO:PomBase.
DR GO; GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IBA:GO_Central.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; ISO:PomBase.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome.
FT CHAIN 1..1191
FT /note="Probable inositol polyphosphate 5-phosphatase
FT C9G1.10c"
FT /id="PRO_0000316865"
FT REGION 1..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 1191 AA; 131274 MW; 7BAB86AD85F3A7E7 CRC64;
MASRQGFSNV NEDEPELPPS VLSLKSKFES LSTGDLTNLD EKTAKRRTVK GCKNGTSEPN
VFKARPIPPP RQVSSTIGSS TGRKVSGSIQ RLASNFKNPS NPHADVSKID RLPSDSSESH
VATPSSPTIS NSFVSVSPLL KRPQQKGPEI SFQSSVQSTK GNDLMKHDDT NNHQIPPPKP
NFSSKAGSSS PISVSPLKNV KAYISQSPTH SEASSVLSSE EEEENVINSS KSVPSFDLHD
PFSQTFGKEC PISTAPPVLN IGDRSLETPP PIPSPRPPQP VAVEAIQQSR AVISQQLPLH
VSPRKPPKPP LRKVSTQRSS SPIENLATKS DASLVTGLQS SPYTHIAPAS EMSLIPEKPR
LPPRPSHTLS ELSSPALTSE NLSSKPSPLF PPPPPRVKSL ATNKPVSMPV STEQSDPSVA
ASSSSSSQLD VVLKGSIPDT SSVRRNPPCF VNGVESINVD FEARIFDVSG DRLVLAGNGG
LRVYDTVTGL CHWHMPLGDT KVTSLSFKSS PENYSDDGRF VWFGTRDGML WEVDVQNHHI
VTKKSVSNCP ITYVMVYKNE MWTLDDMGKL YVWQEDEIMG LSIQSTPHSI RTIPHATHAM
VLDNRLLWVV VGKSIYVYDP STSENESASV LAKPMTPPGL IGDISCGTTI SNFTDLVFYG
HVDGKISIFS KTQYRFLELI TSSSFYRICS LVGVGNTLWA AYTTGMIYVF DVSESPWRLL
KSWHGHKASH NGATTILGID VNSVWKAKRL QVVSMASSVV KFWDGLMMGD WLATEMRSRF
PEYSNFTDVS ILICSWNAGA SKPSDLDSDT IGASMIPMMI RDNGYPDIVV FGFQELVDLE
NKRLTARSIL SKSSSKGGSS NSANISSQYR LWREKLESEM MRVSSNDDYQ VLVCENLVGL
FSCVFVKNKL QSKIRMLQST TVKTGLGGLH GNKGAIVVRF LVDDTSYCIV NCHLAAGQSN
KAARNNDLAT ILDNASLFPE NDETDQLNTF VGGGDGSLIM DHEVCVLHGD LNYRINTLRP
KALDLIKKND IKTLLQSDQL LVERKRNAGF RLRTFTEPEI TFAPTYKYDV HSEQYDSSEK
KRVPAWCDRI CYRGSPDYIS AENYTRYELK ASDHRPVSAL IHSKAKMVNA QSQGSTWDVV
KRKWIEYADE FKRKAKITYV MNYTSVSYQT AEQYLSGNNW NVQNALKQVS S
