ID   YEA4_KLULA              Reviewed;         328 AA.
AC   Q00974;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=UDP-N-acetylglucosamine transporter YEA4;
DE   AltName: Full=Golgi UDP-GlcNAc transporter;
GN   Name=YEA4; Synonyms=MNN2; OrderedLocusNames=KLLA0B03157g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 201343 / MG1/2;
RX   PubMed=8650202; DOI=10.1073/pnas.93.12.5963;
RA   Abeijon C., Robbins P.W., Hirschberg C.B.;
RT   "Molecular cloning of the Golgi apparatus uridine diphosphate-N-
RT   acetylglucosamine transporter from Kluyveromyces lactis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:5963-5968(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC       UDP-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into Golgi
CC       vesicles where glycosyltransferases function.
CC       {ECO:0000269|PubMed:8650202}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF106080; AAC49313.1; -; Genomic_DNA.
DR   EMBL; CR382122; CAH02066.1; -; Genomic_DNA.
DR   RefSeq; XP_451673.1; XM_451673.1.
DR   AlphaFoldDB; Q00974; -.
DR   SMR; Q00974; -.
DR   STRING; 28985.XP_451673.1; -.
DR   TCDB; 2.A.7.10.1; the drug/metabolite transporter (dmt) superfamily.
DR   EnsemblFungi; CAH02066; CAH02066; KLLA0_B03157g.
DR   GeneID; 2897052; -.
DR   KEGG; kla:KLLA0_B03157g; -.
DR   eggNOG; KOG1583; Eukaryota.
DR   HOGENOM; CLU_033007_1_1_1; -.
DR   InParanoid; Q00974; -.
DR   OMA; NYAFDFN; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..328
FT                   /note="UDP-N-acetylglucosamine transporter YEA4"
FT                   /id="PRO_0000213360"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  36667 MW;  93A31FACA804D1EF CRC64;
     MSFVLILSLV FGGCCSNVIS FEHMVQGSNI NLGNIVTFTQ FVSVTLIQLP NALDFSHFPF
     RLRPRHIPLK IHMLAVFLFF TSSVANNSVF KFDISVPIHI IIRCSGTTLT MIIGWAVCNK
     RYSKLQVQSA IIMTLGAIVA SLYRDKEFSM DSLKLNTDSV GMTQKSMFGI FVVLVATALM
     SLLSLLNEWT YNKCGKHWKE TLFYSHFLAL PLFMLGYTRL RDEFRDLLIS SDSMDIPIVK
     LPIATKLFML IANNVTQFIC IKGVNMLASN TDALTLSVVL LVRKFVSLLL SVYIYKNVLS
     VTAYLGTITV FLGAGLYSYG SVKTALPR