ID   CB28_CONMR              Reviewed;          77 AA.
AC   P0DPG6;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Conotoxin Mr8.2 {ECO:0000305};
DE   AltName: Full=Mr096 {ECO:0000303|PubMed:23152539};
DE   Flags: Precursor;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=23152539; DOI=10.1074/mcp.m112.021469;
RA   Dutertre S., Jin A.H., Kaas Q., Jones A., Alewood P.F., Lewis R.J.;
RT   "Deep venomics reveals the mechanism for expanded peptide diversity in cone
RT   snail venom.";
RL   Mol. Cell. Proteomics 12:312-329(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23152539}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:23152539}.
CC   -!- DOMAIN: The cysteine framework is VIII (C-C-C-C-C-C-C-C-C-C).
CC       {ECO:0000305}.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The gene superfamily associated with this precursor was
CC       described as 'B superfamily' in PubMed:23152539, but this name was
CC       already assigned to the conantokin precursors, therefore the
CC       superfamily was renamed 'B2 superfamily'. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin B2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0DPG6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..32
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444201"
FT   CHAIN           33..77
FT                   /note="Conotoxin Mr8.2"
FT                   /evidence="ECO:0000305|PubMed:23152539"
FT                   /id="PRO_0000444202"
SQ   SEQUENCE   77 AA;  8845 MW;  2C1FDA82235435C1 CRC64;
     MLRLITAAVL VSACLAYPQK KRTPPQTRPT SRALVSQCRP CPTCRECKCR ECKCRECQCR
     IHSCLSAWDS RGIWMRT