ID   YEDS_ECOLX              Reviewed;         357 AA.
AC   J9RX10;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Outer membrane protein YedS;
DE   Flags: Precursor;
GN   Name=yedS {ECO:0000303|PubMed:23318808};
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   INDUCTION.
RC   STRAIN=CH4;
RX   PubMed=23318808; DOI=10.1128/aac.02445-12;
RA   Warner D.M., Yang Q., Duval V., Chen M., Xu Y., Levy S.B.;
RT   "Involvement of MarR and YedS in carbapenem resistance in a clinical
RT   isolate of Escherichia coli from China.";
RL   Antimicrob. Agents Chemother. 57:1935-1937(2013).
CC   -!- FUNCTION: Forms pores that allow passive diffusion of small molecules
CC       across the outer membrane (By similarity). Plays a role in resistance
CC       to carbapenems; this carbapenem-resistant, noncarbapenemase-producing
CC       clinical isolate has a deletion in ompF and a mutated marR gene that
CC       does not induce expression of this protein. However if this gene is
CC       overexpressed, or if wild-type marR is introduced, this leads to
CC       decreased resistance to the carbapenem antibiotics ertapenem, imipenem
CC       and meropenem (PubMed:23318808). {ECO:0000250|UniProtKB:P06996,
CC       ECO:0000269|PubMed:23318808}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:23318808}; Multi-pass membrane protein.
CC   -!- INDUCTION: Expression induced by marR. {ECO:0000269|PubMed:23318808}.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; JX392406; AFR46005.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9RX10; -.
DR   SMR; J9RX10; -.
DR   STRING; 481805.EcolC_1679; -.
DR   eggNOG; COG3203; Bacteria.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..357
FT                   /note="Outer membrane protein YedS"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5003826863"
SQ   SEQUENCE   357 AA;  39714 MW;  A378E3211A7D7CFB CRC64;
     MKRKVLAMLV PALLVAGAAN AAEIYNKDGN KVDFYGKMVG ERIWSNTDDN NSENEDTSYA
     RFGVKGESQI TSELTGFGQF EYNLDASKPE GSNQEKTRLT FAGLKYNELG SFDYGRNYGV
     AYDAAAYTDM LVEWGGDSWA SADNFMNGRT NGVATYRNSD FFGLVDGLNF AVQYQGKNSN
     RGVTKQNGDG YALSVDYNIE GFGFVGAYSK SDRTNEQAGD GYGDNAEVWS LAAKYDANNI
     YAAMMYGETR NMTVLANDHF ANKTQNFEAV VQYQFDFGLR PSLGYVYSKG KDLYARDGHK
     GVDADRVNYI EVGTWYYFNK NMNVYTAYKF NLLDKDDAAI TDAATDDQFA VGIVYQF