ID   YEE2_SCHPO              Reviewed;        1213 AA.
AC   O13818; Q9USA8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Uncharacterized PH domain-containing protein C19A8.02;
GN   ORFNames=SPAC19A8.02;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 492-726, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10759889}. Nucleus
CC       membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:10759889}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, spindle pole body {ECO:0000269|PubMed:10759889}.
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DR   EMBL; CU329670; CAB11638.1; -; Genomic_DNA.
DR   EMBL; AB027907; BAA87211.1; -; Genomic_DNA.
DR   PIR; T37959; T37959.
DR   RefSeq; NP_593790.1; NM_001019219.2.
DR   AlphaFoldDB; O13818; -.
DR   BioGRID; 278690; 6.
DR   STRING; 4896.SPAC19A8.02.1; -.
DR   iPTMnet; O13818; -.
DR   MaxQB; O13818; -.
DR   PaxDb; O13818; -.
DR   PRIDE; O13818; -.
DR   EnsemblFungi; SPAC19A8.02.1; SPAC19A8.02.1:pep; SPAC19A8.02.
DR   GeneID; 2542216; -.
DR   KEGG; spo:SPAC19A8.02; -.
DR   PomBase; SPAC19A8.02; -.
DR   VEuPathDB; FungiDB:SPAC19A8.02; -.
DR   eggNOG; ENOG502QU87; Eukaryota.
DR   HOGENOM; CLU_001720_0_0_1; -.
DR   InParanoid; O13818; -.
DR   OMA; APGRDCD; -.
DR   PhylomeDB; O13818; -.
DR   PRO; PR:O13818; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0032541; C:cortical endoplasmic reticulum; ISO:PomBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; ISM:PomBase.
DR   GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; ISO:PomBase.
DR   CDD; cd07609; BAR_SIP3_fungi; 1.
DR   CDD; cd13280; PH_SIP3; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039463; Sip3/Lam1_BAR.
DR   InterPro; IPR042067; Sip3_PH.
DR   InterPro; IPR031968; VASt.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF16016; VASt; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51778; VAST; 1.
PE   4: Predicted;
KW   Cytoplasm; Cytoskeleton; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..1213
FT                   /note="Uncharacterized PH domain-containing protein
FT                   C19A8.02"
FT                   /id="PRO_0000310806"
FT   TRANSMEM        996..1016
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1025..1045
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          289..390
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          776..945
FT                   /note="VASt"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01114"
SQ   SEQUENCE   1213 AA;  140562 MW;  46693C597D0E7158 CRC64;
     MAAPANASSK KDHVIPVLLN ECSIDSPSFR ASMYYLGNQI KAFNEWSHDF LCCCNKFIES
     IMAIEPIVAS MSLNAMPSNV ASGFFDPDYA TTALLHGQDL FRSSYMVQLQ QAKNLRKFIV
     APLDLFRDSK VKPLLQLNDR FKAEQAKYDA EVLRYSSLGH SKDLSQMRDE AKSLYEARKS
     YFTVALQYVV RVTSFRSSID FIVIESICKF SIETFRLTDR LHESNRHIND QLIRLLSYET
     KLKESYPSLK RIVSNVFDRI EKEILKRVQP PTNLDAYRFD PQQICQTNAT KRQGWLLRNI
     SSSKADNKAI WRKYWFFVDN GYVGYLINDA NGGVFESEKI GVLLCKFSVL PSNHRKFCFQ
     IKTKSVSYIL QAETHMEMLE WGSVINNARE HCINSGISAN RILSPTLPSF SAKATSIINP
     QVNGRSNSTG KIGKNYRPRR TYSGRLLCGP NNYEVSTIMR SPTISTVPPP KYLSNSINGA
     KFLNPLAPWT LVNAPLITNL THETITSLLD QEAFFHGNSP CALLANFWGS VNYGHVLERQ
     NVYIEDLSNP SYKRLAREIH IEKLPSELKL RNAEFRGIFG ESEASTVLFV CRVCSKREDQ
     IRMPGRMYCT MKGIYIYYNI NGLVLIEHFP ISSILNVKQF ASTKCDYFYM NIQNIGTVRF
     RLYLDSSKAL TDRLNVLLCN YIADKPNSSI QLLSCIKRLN DDVKRFERGG DDNALKSYGV
     QPSQEDLLIR RGRSSRALTN LINKNESNDS FMEDLRDFKI AMLPKETVQV VRSHHLDDIV
     FDRVYNVSTK ALFHIVFGDR STVLSGAYNL HGVDDVEFLP WGKDPKTNLS RRYINYKVYN
     YDQEGQCQSY HYEDCQIMDV RNDYHLYIMT WLHHSWTLPY RDYFKIVTKT SISHLRREKS
     RLLISVGLEW IVKPFAISKV IEAECRKLAI KYIKTEVNFL EKATRRARNQ PLIAIINQYG
     RVGDYNESMV YRRKIPFNCE LKNLSIIDII RNNWWLFLQG LAIDLLKLPW AVFHIFLRYL
     FSHSFLVIIF ACSVILNLSL MFCFGAKYWD ERQNNKFVGQ VFDEFKNIET SARYVYMKDV
     DDLLVGLPTY LHPNVTYPSE CLQSFALKSS PQKSHWLRKR NYIAEKRKKI LENLASLNYY
     EYIIHEDAVY QYIQQELLGC DKAREFDLYP PSMQRYCDSC TQDWRNRTLF FGKDTLATRL
     LTLETVENAD YAA