ID   YEE6_SCHPO              Reviewed;         397 AA.
AC   O13822;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized oxidoreductase C19A8.06;
DE            EC=1.-.-.-;
GN   ORFNames=SPAC19A8.06;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB11642.1; -; Genomic_DNA.
DR   PIR; T37955; T37955.
DR   RefSeq; NP_593786.1; NM_001019215.2.
DR   AlphaFoldDB; O13822; -.
DR   SMR; O13822; -.
DR   STRING; 4896.SPAC19A8.06.1; -.
DR   SwissPalm; O13822; -.
DR   MaxQB; O13822; -.
DR   PaxDb; O13822; -.
DR   EnsemblFungi; SPAC19A8.06.1; SPAC19A8.06.1:pep; SPAC19A8.06.
DR   GeneID; 2542391; -.
DR   KEGG; spo:SPAC19A8.06; -.
DR   PomBase; SPAC19A8.06; -.
DR   VEuPathDB; FungiDB:SPAC19A8.06; -.
DR   eggNOG; KOG1208; Eukaryota.
DR   HOGENOM; CLU_010194_44_1_1; -.
DR   InParanoid; O13822; -.
DR   OMA; NIEDPLW; -.
DR   PhylomeDB; O13822; -.
DR   Reactome; R-SPO-5365859; RA biosynthesis pathway.
DR   PRO; PR:O13822; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0031965; C:nuclear membrane; ISO:PomBase.
DR   GO; GO:0016491; F:oxidoreductase activity; ISM:PomBase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Oxidoreductase; Reference proteome.
FT   CHAIN           1..397
FT                   /note="Uncharacterized oxidoreductase C19A8.06"
FT                   /id="PRO_0000310782"
FT   BINDING         79..100
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         237
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   397 AA;  45227 MW;  C4D428969E612404 CRC64;
     MSVVCSCLLP TPSTDFVNQR NMPIPIIAHI AQFKYEHLIT HWAQYTKAAI AVSTIAAFKF
     WTSGRTTTWE RKMNGMVVMV TGGSSGIGQV VVEKLASLGA QVVILLRTEP DQFTVDYIMD
     LRKRTKNQLI YTEVCDLSSM LSVRKFATKW IDCTPIRRLD MIVLCSGVLL PPFMDRQTTE
     EGVELQWATN FLGPYQLLRI LRPVIYGQPG HREVRIVAAT CSSYILGNID FNDLDLSNHP
     YPRKSPWKVV GNAKLALMTY LYDFQKKAEA HERPDKMPCN LHTIMANPGV VRTPGFRRVV
     SFGKVWGLFL YLLLWPFWWL LLKGTIHGAQ SFFHAICSPE FASITQPVLV NECSIVEYSR
     KEITDPEFAE KLIKAADAQI DEVEKQYKKK KIKKSKK