ID   YEFM_SHIFL              Reviewed;          90 AA.
AC   Q83KJ8; Q7C112;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Antitoxin YefM;
GN   Name=yefM; OrderedLocusNames=SF2079, S2201;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
RN   [3]
RP   POSSIBLE FUNCTION.
RC   STRAIN=301 / Serotype 2a, and ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Antitoxin that counteracts the effect of the YoeB mRNA interferase.
CC       YefM binds to the promoter region of the yefM-yeoB operon to repress
CC       transcription, YeoB acts as a corepressor (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with YoeB which inhibits its toxin activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phD/YefM antitoxin family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN43619.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17448.1; -; Genomic_DNA.
DR   RefSeq; NP_707912.1; NC_004337.2.
DR   RefSeq; WP_001259256.1; NZ_WPGW01000112.1.
DR   AlphaFoldDB; Q83KJ8; -.
DR   SMR; Q83KJ8; -.
DR   STRING; 198214.SF2079; -.
DR   EnsemblBacteria; AAN43619; AAN43619; SF2079.
DR   EnsemblBacteria; AAP17448; AAP17448; S2201.
DR   GeneID; 1025294; -.
DR   GeneID; 58390412; -.
DR   KEGG; sfl:SF2079; -.
DR   KEGG; sfx:S2201; -.
DR   PATRIC; fig|198214.7.peg.2489; -.
DR   HOGENOM; CLU_155837_1_0_6; -.
DR   OMA; MRIVSFT; -.
DR   OrthoDB; 2047723at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006442; Antitoxin_Phd/YefM.
DR   InterPro; IPR036165; YefM-like_sf.
DR   Pfam; PF02604; PhdYeFM_antitox; 1.
DR   SUPFAM; SSF143120; SSF143120; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Toxin-antitoxin system;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..90
FT                   /note="Antitoxin YefM"
FT                   /id="PRO_0000213740"
SQ   SEQUENCE   90 AA;  10199 MW;  07CC37F3B4A2235D CRC64;
     MRTISYSEAR QNLSATMMKA VEDHAPILIT RQNGEACVLM SLEEYNSLEE TAYLLRSPAN
     ARRLMDSIDS LKSGKGTEKD IIEWVMLPTY