ID   YEFM_STRCO              Reviewed;          87 AA.
AC   Q9Z4V7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Antitoxin YefM;
DE   AltName: Full=ORFU1E;
GN   OrderedLocusNames=SCO2235; ORFNames=SCBAC17D6.02;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=10517584; DOI=10.1099/00221287-145-9-2313;
RA   Fink D., Falke D., Wohlleben W., Engels A.;
RT   "Nitrogen metabolism in Streptomyces coelicolor A3(2): modification of
RT   glutamine synthetase I by an adenylyltransferase.";
RL   Microbiology 145:2313-2322(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       A probable antitoxin for the putative mRNA interferase YeoB (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with YoeB which inhibits its toxin activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phD/YefM antitoxin family. {ECO:0000305}.
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DR   EMBL; Y17736; CAB38327.1; -; Genomic_DNA.
DR   EMBL; AL939111; CAC37261.1; -; Genomic_DNA.
DR   PIR; T51758; T51758.
DR   RefSeq; NP_626485.1; NC_003888.3.
DR   RefSeq; WP_003976578.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9Z4V7; -.
DR   SMR; Q9Z4V7; -.
DR   STRING; 100226.SCO2235; -.
DR   GeneID; 1097668; -.
DR   KEGG; sco:SCO2235; -.
DR   PATRIC; fig|100226.15.peg.2273; -.
DR   eggNOG; COG2161; Bacteria.
DR   HOGENOM; CLU_155837_1_1_11; -.
DR   InParanoid; Q9Z4V7; -.
DR   OMA; SIMETNY; -.
DR   PhylomeDB; Q9Z4V7; -.
DR   Proteomes; UP000001973; Chromosome.
DR   InterPro; IPR006442; Antitoxin_Phd/YefM.
DR   InterPro; IPR036165; YefM-like_sf.
DR   Pfam; PF02604; PhdYeFM_antitox; 1.
DR   SUPFAM; SSF143120; SSF143120; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..87
FT                   /note="Antitoxin YefM"
FT                   /id="PRO_0000213743"
SQ   SEQUENCE   87 AA;  9693 MW;  415D2B5882B19D46 CRC64;
     MSITASEARQ NLFPLIEQVN EDHAPVHITS RKGNAVLMSE EDFTAWTETV HLLRSPRNAR
     RLLDSIAEAE AGDATEHDLI DPDAERA