YEG5_SCHPO
ID YEG5_SCHPO Reviewed; 1151 AA.
AC O13987;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ankyrin and IPT/TIG repeat-containing protein C26H5.05;
GN ORFNames=SPAC26H5.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:16823372};
CC Single-pass membrane protein {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB16191.1; -; Genomic_DNA.
DR PIR; T38424; T38424.
DR RefSeq; NP_594452.1; NM_001019881.2.
DR AlphaFoldDB; O13987; -.
DR SMR; O13987; -.
DR BioGRID; 279154; 155.
DR IntAct; O13987; 2.
DR STRING; 4896.SPAC26H5.05.1; -.
DR iPTMnet; O13987; -.
DR MaxQB; O13987; -.
DR PaxDb; O13987; -.
DR PRIDE; O13987; -.
DR EnsemblFungi; SPAC26H5.05.1; SPAC26H5.05.1:pep; SPAC26H5.05.
DR GeneID; 2542701; -.
DR KEGG; spo:SPAC26H5.05; -.
DR PomBase; SPAC26H5.05; -.
DR VEuPathDB; FungiDB:SPAC26H5.05; -.
DR eggNOG; KOG3836; Eukaryota.
DR HOGENOM; CLU_284721_0_0_1; -.
DR InParanoid; O13987; -.
DR OMA; RVETNML; -.
DR PhylomeDB; O13987; -.
DR PRO; PR:O13987; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:PomBase.
DR GO; GO:0071458; C:integral component of cytoplasmic side of endoplasmic reticulum membrane; IC:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0101026; P:mitotic nuclear membrane biogenesis; IMP:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Vacuole.
FT CHAIN 1..1151
FT /note="Ankyrin and IPT/TIG repeat-containing protein
FT C26H5.05"
FT /id="PRO_0000316206"
FT TRANSMEM 1113..1133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 658..739
FT /note="IPT/TIG"
FT REPEAT 861..890
FT /note="ANK 1"
FT REPEAT 894..923
FT /note="ANK 2"
FT REGION 77..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 127698 MW; 6D6A8AE5AA4D4E97 CRC64;
MNLEFSFGNL IAKNTENSTK EEGTWEVNKL MKFSSEEGRS SSDDYMFSSP DFEKAGNGDA
EMREFFNFDG LPDQGLNLPS IAPPSLSHAS SPNLSNSQDE AECLPSDRQQ DYINPSLHLN
RTVFPTPQHS ISDANFLANT VDQPLGDNPM FGESDVYLLK MDPMKQAPYE AGFNSVKSSG
AIEDPLQFRQ PITMLETPFN ESINTLTPYA EDYAFSSLNT SAPPLSNKEY AFSVNHLPAI
NEHKWKSRVE TNMLFELRIK SNDNQSVPFE YLRLPSWAHR EDKKRSSKPQ PLQPDPETVI
HLVPTVLAGD KSSVVKTCCT RCLLRERKRN ARSQATKDAC MPNYTKLKAY ERNMTDASPE
EKQQFRIKLL NQFPKLEDID EDRMIMVFTG PEYVRLQLDG NERVAHINAR ITCYSSHQSC
PYFHIIWDLY SMSRLVDRLV FPEPVTVLDD HKSRNLTKSE KTGKSNSQQA PSNHVLSKSN
TVPNLVTGFP TRSDNPPNEK RRRTSSSENS RALDIQLSAS DSHSPNSKST LKSVEGSAFS
MSKSPSVLSM TTPSGVSPSI SKNGFHVVRV PSDAAGFQQR QQQEEGVLEA HTNESAPIAP
FPYCTDDFSF SVEEKSSVNN LLTQFDEVAK PDFVSTPIKE NVDSSFINMT PPDVSHAPLI
SRIIPNKGSI MGGYEVTILG ANFFNGLVCL FGDNPAAVTF SWSESTIIAT CPPATNAGTV
PVTFQNYNSS SEAPVMFTYE DNLDNELYKL TVQVLGLKLT GSIQNPLTLS KKLLSSWRDD
FAQYITNSIK QPPNSESKGQ SKKTLLHDSN MESLKSVISR IVKKDSNQSD DSVESTILAA
FALVTDTTTP YLSDFSLVNE SGRSLLHLTA ACGLSNASTF LCNAGCDVNK RDALGYTPLH
YASLYDHKDI CVNLLSNGAK PDVIGASGKK PIDLSSSEPI KLVFKEANNE QAQSISRSLI
KDSEGSINTN ETLESTSIVN EIEESAVQTK SYSESMWNKT VTMFPSLQEL PQNYMSEVPS
MMQKAMLSTL KSISAIPDDV PPPYSEFADD TTAQAGSSKR DSAISEDPDH HKSVWWSLRW
QSRLVGRGKS TALTPEETRA IQEQAKTLKK AGMDFMLFSF WLPALLLLSI FGLRSYAQMI
GGYLYRCIIG I
