ID   YEGD_ECOLI              Reviewed;         450 AA.
AC   P36928; P76392;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Uncharacterized chaperone protein YegD;
GN   Name=yegD; OrderedLocusNames=b2069, JW2054;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-147.
RX   PubMed=6094528; DOI=10.1016/s0021-9258(18)89806-4;
RA   Nakabeppu Y., Miyata T., Kondo H., Iwanaga S., Sekiguchi M.;
RT   "Structure and expression of the alkA gene of Escherichia coli involved in
RT   adaptive response to alkylating agents.";
RL   J. Biol. Chem. 259:13730-13736(1984).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=7940673; DOI=10.1016/0968-0004(94)90067-1;
RA   Borodovsky M., Koonin E.V., Rudd K.E.;
RT   "New genes in old sequence: a strategy for finding genes in the bacterial
RT   genome.";
RL   Trends Biochem. Sci. 19:309-313(1994).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA   Borodovsky M., Rudd K.E., Koonin E.V.;
RT   "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT   genome.";
RL   Nucleic Acids Res. 22:4756-4767(1994).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; U00096; AAC75130.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15927.1; -; Genomic_DNA.
DR   EMBL; K02498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; D64973; D64973.
DR   RefSeq; NP_416573.4; NC_000913.3.
DR   RefSeq; WP_000469708.1; NZ_LN832404.1.
DR   AlphaFoldDB; P36928; -.
DR   SMR; P36928; -.
DR   BioGRID; 4259695; 212.
DR   IntAct; P36928; 6.
DR   STRING; 511145.b2069; -.
DR   jPOST; P36928; -.
DR   PaxDb; P36928; -.
DR   PRIDE; P36928; -.
DR   DNASU; 947234; -.
DR   EnsemblBacteria; AAC75130; AAC75130; b2069.
DR   EnsemblBacteria; BAA15927; BAA15927; BAA15927.
DR   GeneID; 947234; -.
DR   KEGG; ecj:JW2054; -.
DR   KEGG; eco:b2069; -.
DR   PATRIC; fig|511145.12.peg.2146; -.
DR   EchoBASE; EB2116; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_033976_0_0_6; -.
DR   InParanoid; P36928; -.
DR   OMA; HEYLEGY; -.
DR   PhylomeDB; P36928; -.
DR   BioCyc; EcoCyc:EG12200-MON; -.
DR   PRO; PR:P36928; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   CDD; cd10231; YegD_like; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR042054; YegD-like.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 2.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00329; HSP70_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..450
FT                   /note="Uncharacterized chaperone protein YegD"
FT                   /id="PRO_0000078660"
FT   CONFLICT        145..147
FT                   /note="LPE -> GIL (in Ref. 4)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   450 AA;  49371 MW;  C25A8AE1D6F44C2D CRC64;
     MFIGFDYGTA NCSVAVMRDG KPHLLKMEND STLLPSMLCA PTREAVSEWL YRHHDVPADD
     DETQALLRRA IRYNREEDID VTAKSVQFGL SSLAQYIDDP EEVWFVKSPK SFLGASGLKP
     QQVALFEDLV CAMMLHIRQQ AQAQLPEAIT QAVIGRPINF QGLGGDEANT QAQGILERAA
     KRAGFRDVVF QYEPVAAGLD YEATLQEEKR VLVVDIGGGT TDCSLLLMGP QWRSRLDREA
     SLLGHSGCRI GGNDLDIALA FKNLMPLLGM GGETEKGIAL PILPWWNAVA INDVPAQSDF
     YSSANGRLLN DLVRDAREPE KVALLQKVWR QRLSYRLVRS AEECKIALSS VAETRASLPF
     ISNELATLIS QRGLESALSQ PLTRILEQVQ LALDNAQEKP DVIYLTGGSA RSPLIKKALA
     EQLPGIPIAG GDDFGSVTAG LARWAEVVFR