ID   YEGI_ECO57              Reviewed;         646 AA.
AC   Q8X7J8;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Protein kinase YegI {ECO:0000250|UniProtKB:P76393};
DE            EC=2.7.-.- {ECO:0000255|PROSITE-ProRule:PRU00159};
GN   Name=yegI; OrderedLocusNames=Z3239, ECs2879;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Probable serine/threonine kinase.
CC       {ECO:0000250|UniProtKB:P76393}.
CC   -!- PTM: Autophosphorylated. {ECO:0000250|UniProtKB:P76393}.
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DR   EMBL; AE005174; AAG57133.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36302.2; -; Genomic_DNA.
DR   PIR; A85834; A85834.
DR   PIR; G90988; G90988.
DR   RefSeq; NP_310906.2; NC_002695.1.
DR   RefSeq; WP_001301756.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X7J8; -.
DR   STRING; 155864.EDL933_3146; -.
DR   EnsemblBacteria; AAG57133; AAG57133; Z3239.
DR   EnsemblBacteria; BAB36302; BAB36302; ECs_2879.
DR   GeneID; 916581; -.
DR   KEGG; ece:Z3239; -.
DR   KEGG; ecs:ECs_2879; -.
DR   PATRIC; fig|386585.9.peg.3011; -.
DR   eggNOG; COG4248; Bacteria.
DR   HOGENOM; CLU_022304_0_0_6; -.
DR   OMA; LADCPWC; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR016960; YegI-like.
DR   PIRSF; PIRSF030823; UCP030823_PK_HhH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Transferase.
FT   CHAIN           1..646
FT                   /note="Protein kinase YegI"
FT                   /id="PRO_0000169124"
FT   DOMAIN          13..300
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        141
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         19..27
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         39
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   646 AA;  71177 MW;  4BF8DB25A0B40B07 CRC64;
     MKPTLYTATG ECVTPGRELG KGGEGAVYDI NEFVDSVAKI YHTPPPALKQ DKLAFMAATA
     DAQLLNYVAW PQATLHGGRG GKVIGFMMPK VSGKEPIHMI YSPAHRRQSY PHCAWDFLLY
     VARNIASSFA TVHEHGHVVG DVNQNSFMVG RDSKVVLIDS DSFQINANGT LHLCEVGVSH
     FTPPELQTLP SFVGFERTAN HDNFGLALLI FHVLFGGRHP YSGVPLISDA GNALETDIAH
     FRYAYASDNQ RRGLKPPPRS IPLSMLPGDV EAMFQQAFTE SGVATARPTA KAWVAALDLL
     RQQLKKCTVS AMHVYPGHLT DCPWCALDNQ GVIYFIDLGE EVITTSGDFV LAKVWAMVMA
     SVAPPALQLP LPDHFQPTGR PLPLGLLRRE YIILIEIALS ALSLLLCGLQ AEPRYIILVP
     VLAAIWIIGS LTSKVYKAEI QQRREAFNRA KMDYDHLVSQ IQQLGGLEGF IAKRAMLEKM
     KDEILGLPEE EKRALAALHD TARERQKQKF LEGFFIDAAS IPGVGPARKA ALRSFGIETA
     ADVTRRGVKQ VKGFGDHLTQ AVIDWKASCE RRFVFRPNEA VTPAERQAVM AKMAAKRHRL
     ESALTVGATE LQRFRLHAPA RTMPLMEPLR QAAEKLAQAQ ADLSRC