CB39L_HUMAN
ID CB39L_HUMAN Reviewed; 337 AA.
AC Q9H9S4; Q5TAW6; Q6WG71; Q96FG1; Q9BZ33;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 3.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Calcium-binding protein 39-like;
DE AltName: Full=Antigen MLAA-34;
DE AltName: Full=MO25beta;
DE AltName: Full=Mo25-like protein;
GN Name=CAB39L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Monocytic leukemia;
RX PubMed=15755502; DOI=10.1016/j.leukres.2004.09.013;
RA Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.;
RT "Serological identification of immunogenic antigens in acute monocytic
RT leukemia.";
RL Leuk. Res. 29:503-509(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-337.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Component of a complex that binds and activates STK11/LKB1.
CC In the complex, required to stabilize the interaction between
CC CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD
CC (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta):
CC the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
CC catalytic activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H9S4; P20591: MX1; NbExp=3; IntAct=EBI-1047244, EBI-929476;
CC Q9H9S4; Q9UQR0: SCML2; NbExp=3; IntAct=EBI-1047244, EBI-2513111;
CC Q9H9S4; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-1047244, EBI-5235340;
CC -!- MISCELLANEOUS: Found in serum of 50% of patients with acute monocytic
CC leukemia.
CC -!- SIMILARITY: Belongs to the Mo25 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14147.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY288977; AAQ93064.2; -; mRNA.
DR EMBL; AL136218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL138875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010993; AAH10993.2; -; mRNA.
DR EMBL; AK022639; BAB14147.1; ALT_INIT; mRNA.
DR CCDS; CCDS9416.2; -.
DR RefSeq; NP_001073138.1; NM_001079670.2.
DR RefSeq; NP_001274266.1; NM_001287337.1.
DR RefSeq; NP_001274267.1; NM_001287338.1.
DR RefSeq; NP_001274268.1; NM_001287339.1.
DR RefSeq; NP_112187.2; NM_030925.3.
DR RefSeq; XP_011533556.1; XM_011535254.2.
DR RefSeq; XP_011533557.1; XM_011535255.2.
DR RefSeq; XP_011533558.1; XM_011535256.2.
DR RefSeq; XP_016876274.1; XM_017020785.1.
DR RefSeq; XP_016876275.1; XM_017020786.1.
DR RefSeq; XP_016876276.1; XM_017020787.1.
DR RefSeq; XP_016876277.1; XM_017020788.1.
DR PDB; 3ZHP; X-ray; 2.90 A; A/B=5-337.
DR PDBsum; 3ZHP; -.
DR AlphaFoldDB; Q9H9S4; -.
DR SMR; Q9H9S4; -.
DR BioGRID; 123552; 32.
DR ComplexPortal; CPX-2431; LKB1-STRAD-MO25 serine/threonine protein kinase complex, CAB39L-STRADA variant.
DR ComplexPortal; CPX-2869; LKB1-STRAD-MO25 serine/threonine protein kinase complex, CAB39L-STRADB variant.
DR IntAct; Q9H9S4; 7.
DR MINT; Q9H9S4; -.
DR STRING; 9606.ENSP00000479669; -.
DR iPTMnet; Q9H9S4; -.
DR PhosphoSitePlus; Q9H9S4; -.
DR SwissPalm; Q9H9S4; -.
DR BioMuta; CAB39L; -.
DR DMDM; 51338824; -.
DR EPD; Q9H9S4; -.
DR jPOST; Q9H9S4; -.
DR MassIVE; Q9H9S4; -.
DR MaxQB; Q9H9S4; -.
DR PaxDb; Q9H9S4; -.
DR PeptideAtlas; Q9H9S4; -.
DR PRIDE; Q9H9S4; -.
DR ProteomicsDB; 81359; -.
DR Antibodypedia; 23903; 192 antibodies from 30 providers.
DR DNASU; 81617; -.
DR Ensembl; ENST00000347776.9; ENSP00000261669.7; ENSG00000102547.19.
DR Ensembl; ENST00000355854.8; ENSP00000348113.4; ENSG00000102547.19.
DR Ensembl; ENST00000409308.6; ENSP00000386375.1; ENSG00000102547.19.
DR Ensembl; ENST00000410043.5; ENSP00000386328.1; ENSG00000102547.19.
DR Ensembl; ENST00000610540.4; ENSP00000479669.1; ENSG00000102547.19.
DR GeneID; 81617; -.
DR KEGG; hsa:81617; -.
DR MANE-Select; ENST00000409308.6; ENSP00000386375.1; NM_001079670.3; NP_001073138.1.
DR UCSC; uc001vcw.5; human.
DR CTD; 81617; -.
DR DisGeNET; 81617; -.
DR GeneCards; CAB39L; -.
DR HGNC; HGNC:20290; CAB39L.
DR HPA; ENSG00000102547; Low tissue specificity.
DR MIM; 612175; gene.
DR neXtProt; NX_Q9H9S4; -.
DR OpenTargets; ENSG00000102547; -.
DR PharmGKB; PA134913801; -.
DR VEuPathDB; HostDB:ENSG00000102547; -.
DR eggNOG; KOG1566; Eukaryota.
DR GeneTree; ENSGT00390000004360; -.
DR InParanoid; Q9H9S4; -.
DR OMA; NFAVMTK; -.
DR OrthoDB; 865327at2759; -.
DR PhylomeDB; Q9H9S4; -.
DR TreeFam; TF314910; -.
DR PathwayCommons; Q9H9S4; -.
DR Reactome; R-HSA-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR SignaLink; Q9H9S4; -.
DR BioGRID-ORCS; 81617; 8 hits in 1028 CRISPR screens.
DR ChiTaRS; CAB39L; human.
DR GeneWiki; CAB39L; -.
DR GenomeRNAi; 81617; -.
DR Pharos; Q9H9S4; Tbio.
DR PRO; PR:Q9H9S4; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q9H9S4; protein.
DR Bgee; ENSG00000102547; Expressed in decidua and 178 other tissues.
DR ExpressionAtlas; Q9H9S4; baseline and differential.
DR Genevisible; Q9H9S4; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013878; Mo25.
DR PANTHER; PTHR10182; PTHR10182; 1.
DR Pfam; PF08569; Mo25; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..337
FT /note="Calcium-binding protein 39-like"
FT /id="PRO_0000209826"
FT CONFLICT 93
FT /note="G -> E (in Ref. 3; AAH10993)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="A -> V (in Ref. 4; BAB14147)"
FT /evidence="ECO:0000305"
FT HELIX 16..29
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 33..36
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 38..53
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 66..76
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 78..84
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 91..105
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 114..121
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 124..131
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 132..134
FT /evidence="ECO:0007829|PDB:3ZHP"
FT TURN 136..138
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 139..149
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 153..160
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 163..167
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 168..171
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 177..192
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 195..204
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 206..217
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 222..237
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 239..241
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 242..248
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 252..261
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 267..282
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 288..296
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 298..307
FT /evidence="ECO:0007829|PDB:3ZHP"
FT TURN 308..311
FT /evidence="ECO:0007829|PDB:3ZHP"
FT HELIX 316..330
FT /evidence="ECO:0007829|PDB:3ZHP"
SQ SEQUENCE 337 AA; 39088 MW; 5C6C7A83B9B4CA2D CRC64;
MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK EILCGTNEKE
PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI FNNILRRQIG TRSPTVEYIS
AHPHILFMLL KGYEAPQIAL RCGIMLRECI RHEPLAKIIL FSNQFRDFFK YVELSTFDIA
SDAFATFKDL LTRHKVLVAD FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH
NFAIMTKYIS KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK
LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP
