YEGT_ECOLI
ID YEGT_ECOLI Reviewed; 425 AA.
AC P76417; O08013;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Putative nucleoside transporter YegT;
GN Name=yegT; OrderedLocusNames=b2098, JW2085;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Could be involved in nucleoside transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. {ECO:0000305}.
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DR EMBL; U00096; AAC75159.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15967.1; -; Genomic_DNA.
DR PIR; A64977; A64977.
DR RefSeq; NP_416601.1; NC_000913.3.
DR RefSeq; WP_000858484.1; NZ_SSZK01000011.1.
DR AlphaFoldDB; P76417; -.
DR SMR; P76417; -.
DR BioGRID; 4261530; 123.
DR DIP; DIP-11890N; -.
DR IntAct; P76417; 1.
DR STRING; 511145.b2098; -.
DR TCDB; 2.A.1.10.3; the major facilitator superfamily (mfs).
DR PaxDb; P76417; -.
DR PRIDE; P76417; -.
DR EnsemblBacteria; AAC75159; AAC75159; b2098.
DR EnsemblBacteria; BAA15967; BAA15967; BAA15967.
DR GeneID; 66674006; -.
DR GeneID; 946638; -.
DR KEGG; ecj:JW2085; -.
DR KEGG; eco:b2098; -.
DR PATRIC; fig|1411691.4.peg.149; -.
DR EchoBASE; EB3816; -.
DR eggNOG; COG2211; Bacteria.
DR HOGENOM; CLU_013133_1_2_6; -.
DR InParanoid; P76417; -.
DR OMA; GQIGMAF; -.
DR PhylomeDB; P76417; -.
DR BioCyc; EcoCyc:B2098-MON; -.
DR PRO; PR:P76417; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015212; F:cytidine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015213; F:uridine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071702; P:organic substance transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004740; Nuc_H_symport.
DR Pfam; PF03825; Nuc_H_symport; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00889; 2A0110; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..425
FT /note="Putative nucleoside transporter YegT"
FT /id="PRO_0000169130"
FT TOPO_DOM 1..8
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..63
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..90
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..131
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..210
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..287
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..379
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 425 AA; 47359 MW; 0EE5A11356A0543B CRC64;
MKTTAKLSFM MFVEWFIWGA WFVPLWLWLS KSGFSAGEIG WSYACTAIAA ILSPILVGSI
TDRFFSAQKV LAVLMFAGAL LMYFAAQQTT FAGFFPLLLA YSLTYMPTIA LTNSIAFANV
PDVERDFPRI RVMGTIGWIA SGLACGFLPQ ILGYADISPT NIPLLITAGS SALLGVFAFF
LPDTPPKSTG KMDIKVMLGL DALILLRDKN FLVFFFCSFL FAMPLAFYYI FANGYLTEVG
MKNATGWMTL GQFSEIFFML ALPFFTKRFG IKKVLLLGLV TAAIRYGFFI YGSADEYFTY
ALLFLGILLH GVSYDFYYVT AYIYVDKKAP VHMRTAAQGL ITLCCQGFGS LLGYRLGGVM
MEKMFAYQEP VNGLTFNWSG MWTFGAVMIA IIAVLFMIFF RESDNEITAI KVDDRDIALT
QGEVK
