YEH1_SCHPO
ID YEH1_SCHPO Reviewed; 945 AA.
AC O13944; Q9P7N7; Q9US66;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 13-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Oxysterol-binding protein homolog C23H4.01c;
GN ORFNames=SPAC23H4.01c, SPAP27G11.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 391-607, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-419; SER-421 AND
RP SER-503, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10759889}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11656.1; -; Genomic_DNA.
DR EMBL; AB028015; BAA87319.1; -; Genomic_DNA.
DR RefSeq; NP_593405.2; NM_001018838.2.
DR AlphaFoldDB; O13944; -.
DR SMR; O13944; -.
DR BioGRID; 278287; 1.
DR STRING; 4896.SPAC23H4.01c.1; -.
DR iPTMnet; O13944; -.
DR MaxQB; O13944; -.
DR PaxDb; O13944; -.
DR PRIDE; O13944; -.
DR EnsemblFungi; SPAC23H4.01c.1; SPAC23H4.01c.1:pep; SPAC23H4.01c.
DR GeneID; 2541796; -.
DR KEGG; spo:SPAC23H4.01c; -.
DR PomBase; SPAC23H4.01c; -.
DR VEuPathDB; FungiDB:SPAC23H4.01c; -.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_007105_4_0_1; -.
DR InParanoid; O13944; -.
DR OMA; WHLRASN; -.
DR PhylomeDB; O13944; -.
DR Reactome; R-SPO-192105; Synthesis of bile acids and bile salts.
DR PRO; PR:O13944; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR GO; GO:0008142; F:oxysterol binding; ISO:PomBase.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0120015; F:sterol transfer activity; ISO:PomBase.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0035621; P:ER to Golgi ceramide transport; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0030011; P:maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR GO; GO:0015918; P:sterol transport; ISO:PomBase.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
DR PROSITE; PS50866; GOLD; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Lipid transport; Lipid-binding; Phosphoprotein;
KW Reference proteome; Transport.
FT CHAIN 1..945
FT /note="Oxysterol-binding protein homolog C23H4.01c"
FT /id="PRO_0000100392"
FT DOMAIN 1..131
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT DOMAIN 149..243
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 396..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 421
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 503
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 945 AA; 106810 MW; B8E264181310A4BF CRC64;
METVEIRSKS LLIQWLTVES NSLLSWQLHV KRKSIKFDIY HKKNDTSSLL DGSNKNTDRS
ILHTKRQHTH EAGIKKLSAA GLELFYQGER CMSEKPSEGS VYIENGGLYA FVFDNTFSKT
KPKTVTFLLT AQPYNGPRIP NASVHGSPKQ IISGTLLKKR RKKGQGYARR YFTLNMVEGT
ISYYANENSS VMRGKIPLSI AVISVAAETH EINVDSGVEL WNLRAHTHQD WLRWCNALEK
AKNSQTSSKL VVDERTQESS SNQLVSIYSR LRECLDIAQL YRTSRIKSAS SHNFSVPEIR
IQLPGDAKEN KETRTSVEIT AAENAQAAVT LRKVTRQLGS LLHELECFIQ HHEYTKERTA
QSSPSSRMSM DSNFEQHWYD AEDYESTTSQ LNHYSESGAH AADATKSSVA HNEKVEDISD
SDIPIMKTSS NSTSLDADRD SDTSSISDTS SNSSAPHEQL NATSLASTVD ESSRSPPLPE
VESNKENDIK RKQPFHDLMD SSSPDDSSFA NAKSDEEVQK PSVSKNIADG AVISIPKPLT
PKPSDSNSLY PLPHSKVGRR KNIPAITVPP PSILSILRKN IGKDISSIPA PVVSNEPCNL
LQRCAEDLEY SNMLDKANEC DDDIKIFYVA AFAVSNFSNM RHKERSVRKV FSPLLGETFE
LVREDRNYRF LAEKVCHRPL IIACHAESRN WIWNHSPKPI QKFWGKSVEL NTLGPVTIKL
ACGTEFSFMK PACFLKNVAI GEKYVEPYDH MEIVDETTGD KAVIRFKSGG MFSGRSEDVL
VTVIRSNGEE DPKCLQGKWT SHLDFVNTDE GNVIERIWEV GPLVDKPEDH CGMTVFAAQM
NEITDLEKDK LPPTDTRLRP DQRYRENNDL DHAEPLKLEL EQKQRERRKE MEEKDIKWEP
RWFVPSVAGD DEDEDGSGPI WQLKKENNYW ESRENSTWSS CPKLW
