ID   YEIQ_ECOLI              Reviewed;         488 AA.
AC   P33029; P94760;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Uncharacterized oxidoreductase YeiQ;
DE            EC=1.-.-.-;
GN   Name=yeiQ; OrderedLocusNames=b2172, JW2160;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / BHB2600;
RA   Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA   Church G.M.;
RT   "Automated multiplex sequencing of the E.coli genome.";
RL   Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO 48.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxuB
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U00007; AAA60520.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75233.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15981.2; -; Genomic_DNA.
DR   PIR; C64986; C64986.
DR   RefSeq; NP_416677.1; NC_000913.3.
DR   RefSeq; WP_001091940.1; NZ_LN832404.1.
DR   AlphaFoldDB; P33029; -.
DR   SMR; P33029; -.
DR   BioGRID; 4260467; 11.
DR   STRING; 511145.b2172; -.
DR   jPOST; P33029; -.
DR   PaxDb; P33029; -.
DR   PRIDE; P33029; -.
DR   EnsemblBacteria; AAC75233; AAC75233; b2172.
DR   EnsemblBacteria; BAA15981; BAA15981; BAA15981.
DR   GeneID; 946688; -.
DR   KEGG; ecj:JW2160; -.
DR   KEGG; eco:b2172; -.
DR   PATRIC; fig|1411691.4.peg.64; -.
DR   EchoBASE; EB1971; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_0_1_6; -.
DR   InParanoid; P33029; -.
DR   OMA; PWEQMKL; -.
DR   PhylomeDB; P33029; -.
DR   BioCyc; EcoCyc:EG12036-MON; -.
DR   PRO; PR:P33029; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023027; Mannitol_DH_CS.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Uncharacterized oxidoreductase YeiQ"
FT                   /id="PRO_0000170749"
FT   BINDING         27..38
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        48
FT                   /note="L -> R (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   488 AA;  54032 MW;  85F1BFEC7E75ECD8 CRC64;
     MNTIASVTLP HHVHAPRYDR QQLQSRIVHF GFGAFHRAHQ ALLTDRVLNA QGGDWGICEI
     SLFSGDQLMS QLRAQNHLYT VLEKGADGNQ VIIVGAVHEC LNAKLDSLAA IIEKFCEPQV
     AIVSLTITEK GYCIDPATGA LDTSNPRIIH DLQTPEEPHS APGILVEALK RRRERGLTPF
     TVLSCDNIPD NGHVVKNAVL GMAEKRSPEL AGWIKEHVSF PGTMVDRIVP AATDESLVEI
     SQHLGVNDPC AISCEPFIQW VVEDNFVAGR PAWEVAGVQM VNDVLPWEEM KLRMLNGSHS
     FLAYLGYLSG FAHISDCMQD RAFRHAARTL MLDEQAPTLQ IKDVDLTQYA DKLIARFANP
     ALKHKTWQIA MDGSQKLPQR MLAGIRIHQG RETDWSLLAL GVAGWMRYVS GVDDAGNAID
     VRDPLSDKIR ELVAGSSSEQ RVTALLSLRE VFGDDLPDNP HFVQAIEQAW QQIVQFGAHQ
     ALLNTLKI