ID   CB5D1_DANRE             Reviewed;         214 AA.
AC   Q567I9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Cytochrome b5 domain-containing protein 1;
GN   Name=cyb5d1; ORFNames=zgc:112008;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
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DR   EMBL; BC093157; AAH93157.1; -; mRNA.
DR   RefSeq; NP_001017684.1; NM_001017684.2.
DR   AlphaFoldDB; Q567I9; -.
DR   SMR; Q567I9; -.
DR   STRING; 7955.ENSDARP00000072883; -.
DR   PaxDb; Q567I9; -.
DR   PRIDE; Q567I9; -.
DR   Ensembl; ENSDART00000078421; ENSDARP00000072883; ENSDARG00000056007.
DR   GeneID; 795592; -.
DR   KEGG; dre:795592; -.
DR   CTD; 124637; -.
DR   ZFIN; ZDB-GENE-050417-173; cyb5d1.
DR   eggNOG; KOG0537; Eukaryota.
DR   GeneTree; ENSGT00440000037582; -.
DR   InParanoid; Q567I9; -.
DR   OrthoDB; 1534331at2759; -.
DR   PhylomeDB; Q567I9; -.
DR   PRO; PR:Q567I9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000056007; Expressed in testis and 23 other tissues.
DR   ExpressionAtlas; Q567I9; baseline.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..214
FT                   /note="Cytochrome b5 domain-containing protein 1"
FT                   /id="PRO_0000312318"
FT   DOMAIN          4..87
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         39
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         70
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
SQ   SEQUENCE   214 AA;  24896 MW;  23F1575833CC5AA9 CRC64;
     MRRSKYFTPN EVSLHNTIND IWVSYLGKVY DLTPLLEAYK GDVLLKPIIE CAGKDISHWF
     DPKTKDILTH VDPLTGCIKY YTPRGRFIHI PPPCPRTDWA NNFGKPWWKD NRYEVGLLSA
     KTRWIRIINT LTSQEQKLEV CSEESLDEIL HRYLFYNSHA ASYTWKLSGI NLDMSKTLSE
     NGIPEEDEFY CGSPDCNLFS PSICLYFNDD LTEL