ID   CB5D1_PONAB             Reviewed;         228 AA.
AC   Q5R4Q5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Cytochrome b5 domain-containing protein 1;
GN   Name=CYB5D1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
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DR   EMBL; CR861190; CAH93261.1; -; mRNA.
DR   RefSeq; NP_001126919.1; NM_001133447.1.
DR   AlphaFoldDB; Q5R4Q5; -.
DR   SMR; Q5R4Q5; -.
DR   STRING; 9601.ENSPPYP00000008927; -.
DR   Ensembl; ENSPPYT00000009292; ENSPPYP00000008927; ENSPPYG00000007938.
DR   GeneID; 100173936; -.
DR   KEGG; pon:100173936; -.
DR   CTD; 124637; -.
DR   eggNOG; KOG0537; Eukaryota.
DR   GeneTree; ENSGT00440000037582; -.
DR   HOGENOM; CLU_081983_0_0_1; -.
DR   InParanoid; Q5R4Q5; -.
DR   OMA; DLTHFFH; -.
DR   OrthoDB; 1534331at2759; -.
DR   TreeFam; TF324861; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..228
FT                   /note="Cytochrome b5 domain-containing protein 1"
FT                   /id="PRO_0000312317"
FT   DOMAIN          17..100
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         52
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         83
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
SQ   SEQUENCE   228 AA;  26635 MW;  784E5E3EE8A4EEE6 CRC64;
     MSRRGLVAGP DLEYFQRRYF TPAEVAQHNR PEDLWVSYLG RVYDLTSLAQ AYKGNLLLKP
     IVEVAGQDIS HWFDPKTRDI RKHIDPLTGC LRYCTPRGRF VHVPPQLPCS DWANDFGKPW
     WQGSYYEVGR LSAKTRSIRI INTLTSQEHT LEVGVLESIW EILHRYLPYN THAASYTWKY
     EGKNLNMDFT LEENGIRDEE EEFDYLSMDG TLHTPAILLY FNDDLTEL