ID   CB5D1_XENLA             Reviewed;         217 AA.
AC   Q5PPR6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Cytochrome b5 domain-containing protein 1;
GN   Name=cyb5d1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
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DR   EMBL; BC087536; AAH87536.1; -; mRNA.
DR   RefSeq; NP_001088827.1; NM_001095358.1.
DR   AlphaFoldDB; Q5PPR6; -.
DR   SMR; Q5PPR6; -.
DR   DNASU; 496103; -.
DR   GeneID; 496103; -.
DR   KEGG; xla:496103; -.
DR   CTD; 496103; -.
DR   Xenbase; XB-GENE-6252543; cyb5d1.L.
DR   OMA; DLTHFFH; -.
DR   OrthoDB; 1534331at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 496103; Expressed in testis and 17 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..217
FT                   /note="Cytochrome b5 domain-containing protein 1"
FT                   /id="PRO_0000312319"
FT   DOMAIN          6..89
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         41
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         72
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
SQ   SEQUENCE   217 AA;  25241 MW;  C5FD165EE8437533 CRC64;
     MSPVRPRYFT PREVSRHCVL SDLWVSYLGR VYDLTPLLEQ HKGDVLLKPI IAAGGRDISH
     WFNPKTGDVK THIDPQTGCL KYYTPQGRFL HIAPCFPCSG WDNDFGRPWW KDTIYQVGIL
     SSKTRFIRII NTLTSQEQML EVCSEETIWE ILQRYLAYNA HAASYTWKFC GVPLDMDKTL
     QENGVQDEDL EFEELKIDAD LYTPSIHLYF NDDLTEL