ID   YEL1_ASHGO              Reviewed;         707 AA.
AC   Q75D04;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Guanine-nucleotide exchange factor YEL1;
GN   Name=YEL1; OrderedLocusNames=ABR218C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Guanine nucleotide exchange factor for ARF3 required for
CC       localization of ARF3 to the bud neck and tip and involved in actin
CC       patch polarization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Bud neck
CC       {ECO:0000250}. Bud tip {ECO:0000250}. Note=Localizes at the cell
CC       membrane only at the bud neck and bud tip and this localization is
CC       ARF3-dependent. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YEL1 family. {ECO:0000305}.
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DR   EMBL; AE016815; AAS50991.1; -; Genomic_DNA.
DR   RefSeq; NP_983167.1; NM_208520.1.
DR   AlphaFoldDB; Q75D04; -.
DR   SMR; Q75D04; -.
DR   STRING; 33169.AAS50991; -.
DR   EnsemblFungi; AAS50991; AAS50991; AGOS_ABR218C.
DR   GeneID; 4619277; -.
DR   KEGG; ago:AGOS_ABR218C; -.
DR   eggNOG; KOG0929; Eukaryota.
DR   HOGENOM; CLU_017717_0_0_1; -.
DR   InParanoid; Q75D04; -.
DR   OMA; CHIVLFS; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005934; C:cellular bud tip; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..707
FT                   /note="Guanine-nucleotide exchange factor YEL1"
FT                   /id="PRO_0000404223"
FT   DOMAIN          110..304
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   DOMAIN          447..571
FT                   /note="PH"
FT   REGION          127..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  80867 MW;  147CD485995CBC32 CRC64;
     MRSNHLFFRK VMTRLEVHPL NNSRLFCISD SSSTSLYSEP SKGSTIFAQQ ALDRFDWDLS
     IGETAFENMT DDAKMRNDPG MLVGPDGMLI TPELLIASPG KIDVFDCASL DDTAGALEGM
     SLASGEGSNC MQAMRPRSET RSTNTTTSRS VAKQILRNTY GPVRYKDYAN YLGSPENREV
     LREFIALLQP LPVSLLFSLR KLSKSIYFIA EAGAIDAMLE EMSIQWVERH KPLHYQDNYK
     LVHIVLFSLL ILNSDLYNDM AQMKFTSAQF VDNTVYALLR ESPTIDKQSF EAELRVYYDL
     LAMDQLPLHK PPITASHSRD SANPTKKSSV FYSRGHRMER TYSNSSTYSM STISLQRTTT
     AIAAKQTAAV ASWRFHNFSD LPLIYCKEPF DDEMNNTNDS SWLMDHIIQF QEPLGSVSRA
     AAASMVSPTA QPRRKLFNWL KKGQPDSIFK SHHEFGSAEG KWYNARVRIS EGRLYIFNFK
     NQPALDPKTA DLELCRRRAA SYTVQNLFGA MATFVQDNIV YKSNSQTTWN FAITFPKTID
     CETERTYQFQ TSNMTMAQRF VQAATFWSAR ITPLPSAQFE MVSNQEYGWG EKLLSRQVAA
     TDVRLTDWMP LIGIDSIYDE IEDSGDLTVD SQLQNLRVFT EHLTQLLDQH NSYKPKMVEI
     WTQNPSTQQF EMAMENWNRR YLYLNSMYEK HYTYLRALET AFETVTG