ID   YEL1_LACTC              Reviewed;         636 AA.
AC   C5DE74;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Guanine-nucleotide exchange factor YEL1;
GN   Name=YEL1; OrderedLocusNames=KLTH0C06864g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Guanine nucleotide exchange factor for ARF3 required for
CC       localization of ARF3 to the bud neck and tip and involved in actin
CC       patch polarization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Bud neck
CC       {ECO:0000250}. Bud tip {ECO:0000250}. Note=Localizes at the cell
CC       membrane only at the bud neck and bud tip and this localization is
CC       ARF3-dependent. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YEL1 family. {ECO:0000305}.
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DR   EMBL; CU928167; CAR22085.1; -; Genomic_DNA.
DR   RefSeq; XP_002552523.1; XM_002552477.1.
DR   AlphaFoldDB; C5DE74; -.
DR   SMR; C5DE74; -.
DR   STRING; 559295.C5DE74; -.
DR   PRIDE; C5DE74; -.
DR   EnsemblFungi; CAR22085; CAR22085; KLTH0C06864g.
DR   GeneID; 8291392; -.
DR   KEGG; lth:KLTH0C06864g; -.
DR   eggNOG; KOG0929; Eukaryota.
DR   HOGENOM; CLU_017717_0_0_1; -.
DR   InParanoid; C5DE74; -.
DR   OMA; CHIVLFS; -.
DR   OrthoDB; 855811at2759; -.
DR   Proteomes; UP000002036; Chromosome C.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005934; C:cellular bud tip; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..636
FT                   /note="Guanine-nucleotide exchange factor YEL1"
FT                   /id="PRO_0000404224"
FT   DOMAIN          1..203
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   DOMAIN          333..475
FT                   /note="PH"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..234
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  72415 MW;  3C475BB1B22FA60C CRC64;
     MTGLEGAQNL TVADKQLTPD EGVLTESPKM TNIHEIVEDT AASSENGDSE AKEIAAKIRA
     GTLENVEFTE YANYLGTPGN DQILREFLLL LDPLPSSITG TLRKLSSSLY FIAEAANLDT
     ILEALSRQWL SEHNKAHYQD NYKLCHIVMF ALLMLNSTLH NSEADLSFTI EEFRENTINA
     LQKESPDIDV PSFNRELSLC YYQLDNEQLP LLRPPSQPRY SLSGRRTNGN GGHSNMKKAS
     MLSLERFQTN QSLISTQNSM ATLTSRDTTA NSNYRMRNNK PLQKLYLDEP FDAELQDLNG
     TPWLMDSMVN VQEASKANNS TSQLLSSPVT RKRKLMSWFR KHTKDTIFNE NIHAADTDNW
     QHARIRIYQG RLFVYKFKGF GRERSIPRDI HKWSLEMCKR SCSQFHVYNL YGTIASLVQE
     NIVASENSNV SSASFLIDFP HGLDSTSGLS FRFKTRNQDE AKQFTACCNF WSARISPIPS
     AQVEMISNEE YGWSPRLLEG ESGAEQVNLA QVKLAHWKPL VGLDAIFSEL DEGIALWDFD
     SQLGNLRVFT ELLGAQLDEH NAVKPKMVEL WAKKGREYQP QFEAAMENWN NKYLYLNKQY
     QKHLVYLKAL ENAVQFYERS KSVKNPETKN AAKEQS