ID   YEL1_VANPO              Reviewed;         651 AA.
AC   A7TDT6;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Guanine-nucleotide exchange factor YEL1;
GN   Name=YEL1; ORFNames=Kpol_1018p89;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Guanine nucleotide exchange factor for ARF3 required for
CC       localization of ARF3 to the bud neck and tip and involved in actin
CC       patch polarization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Bud neck
CC       {ECO:0000250}. Bud tip {ECO:0000250}. Note=Localizes at the cell
CC       membrane only at the bud neck and bud tip and this localization is
CC       ARF3-dependent. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YEL1 family. {ECO:0000305}.
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DR   EMBL; DS480378; EDO19556.1; -; Genomic_DNA.
DR   RefSeq; XP_001647414.1; XM_001647364.1.
DR   AlphaFoldDB; A7TDT6; -.
DR   SMR; A7TDT6; -.
DR   STRING; 436907.A7TDT6; -.
DR   EnsemblFungi; EDO19556; EDO19556; Kpol_1018p89.
DR   GeneID; 5547914; -.
DR   KEGG; vpo:Kpol_1018p89; -.
DR   eggNOG; KOG0929; Eukaryota.
DR   HOGENOM; CLU_017717_0_0_1; -.
DR   InParanoid; A7TDT6; -.
DR   OMA; CHIVLFS; -.
DR   OrthoDB; 855811at2759; -.
DR   PhylomeDB; A7TDT6; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005934; C:cellular bud tip; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..651
FT                   /note="Guanine-nucleotide exchange factor YEL1"
FT                   /id="PRO_0000404225"
FT   DOMAIN          19..230
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   DOMAIN          362..508
FT                   /note="PH"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          38..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..68
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  75331 MW;  272C08BAF2C06E91 CRC64;
     MESRMSRLVP VRSIDEGDSH DDSRDRISAF ELKSGNGFLE EEVVGVEDEV EEDEGEDEDE
     DDEGSEERSD EYWLAVSIFD GNFDGVNYKE YANYLGSPDR LPVLKEFIKL LQPLPNDLLG
     ALGKLSSRLY FIAEAQNIDR ILEELSGQWM STHTSTIWGD NNSWCHIVLF SLLLLNSDLH
     NDENIGKQSR FTCKMFIENT LYALRKDCER ESKELSKERE QDISQELAIF YENLRFNPLP
     LFTRVDKSAP SVISNIHRRQ RRSSGFSTKS PSIHSLSSTI SHGSSMALES HTTSNWKFHH
     NLPLPILYLK ENFDNEFVGV NGTFWTMDGV LSIAEKKESK NRRSDDQLAS TAEVKSRKTP
     RKLLFSWLKK SKKPSIFEES NSPVAFLNEH SQWSRARIRI TEGRIFIFKL KNNYKDAFLK
     EQTLESMKAL SSSYVVYNLF EALAEVVQEN VVIGTFPSSN NILSNRGNFT ITIPMGLHEY
     KVSLEFQTDT VEEAYAYVQS INFWAARLTP VPSAEFEIVS NDEYGWGSKL LREREKHKKE
     NPTDRNPITN AKVSVWYPLL SLDLLYNEFD NIADQTELIK RLQEIREFTE KLECLIDKHN
     EMKPRMVSAW AGSPYFEKVM DNWNRRYLYL NKQYEKTSIY MKSLTLASEI I