YEL1_ZYGRC
ID YEL1_ZYGRC Reviewed; 833 AA.
AC C5DQU9;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Guanine-nucleotide exchange factor YEL1;
GN Name=YEL1; OrderedLocusNames=ZYRO0B03168g;
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Guanine nucleotide exchange factor for ARF3 required for
CC localization of ARF3 to the bud neck and tip and involved in actin
CC patch polarization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Bud neck
CC {ECO:0000250}. Bud tip {ECO:0000250}. Note=Localizes at the cell
CC membrane only at the bud neck and bud tip and this localization is
CC ARF3-dependent. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the YEL1 family. {ECO:0000305}.
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DR EMBL; CU928174; CAR26160.1; -; Genomic_DNA.
DR RefSeq; XP_002495093.1; XM_002495048.1.
DR AlphaFoldDB; C5DQU9; -.
DR STRING; 559307.C5DQU9; -.
DR EnsemblFungi; CAR26160; CAR26160; ZYRO0B03168g.
DR GeneID; 8202233; -.
DR KEGG; zro:ZYRO0B03168g; -.
DR HOGENOM; CLU_017717_0_0_1; -.
DR InParanoid; C5DQU9; -.
DR Proteomes; UP000008536; Chromosome B.
DR GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR GO; GO:0005934; C:cellular bud tip; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.10.1000.11; -; 1.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48425; SSF48425; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW Reference proteome.
FT CHAIN 1..833
FT /note="Guanine-nucleotide exchange factor YEL1"
FT /id="PRO_0000404230"
FT DOMAIN 185..410
FT /note="SEC7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT DOMAIN 548..696
FT /note="PH"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 95684 MW; B74045A64A66CE38 CRC64;
MNNLSSQNIG TSLDFQESPG EFEEEEEREE DDSSEISSLP PLTQVATASP RMIVSPKMQN
IHLIIQNEDN DSSEVNTPHE DWHANLGLGI QSQPLRNERN VEEHYRTRAK RQTILWAENQ
AEEDTMTQER VRAEAELQVK FEGARAKAEA RAEAEASSRA GLSTGVNGAN RTVEDTKSTG
EQDEMTRKTA ERERRLRAEK ERLLIEEDAR KKAVQVKLEK EKEEEEEGKA AAGRTTAAPE
TPEDQEAQRI AVEIVQGIYK KISHTEYANF LGTKENHRIL KRFIILLEPL PNSLVLSLYK
LVTRIYFIAE AQAIDRILEE LSIRWTTTNP ATHWGSHYNL CHIVLFSLLI LNSDLHNAEN
NQPKFSKEEF TENTLFAVEK ESSKSNFDLA QHEPGIREEL GVYYEALKYM SLPLLKKDEN
KTNVRDSRDS KDTRIRIRRR NSKMSTRSQL NNSTENSSSD DDTSVISSSS PSARREPHYT
SNWKFHHNKP LPRLYRKEPL DEVFVFSNGT SWCVDSGIKM NERDLASSSN NKSTAQRTTR
SRIPSSAGGI FRWITRSKSK SLLHGNKSPV AFFDGNTKWI NVRCRVCEGR IYVFKHYPPS
MGPQNSMQDL DGMKKASDVY FVCSLYESLA TLVQDNVVVN NNHEPSRRGD LDQRGNFTVI
IPASLHRKKT LLEFQTSNVE EAQRFVQCVN FWAARLTPVP TAQFEIVSNE ENGWSPRVLS
GDLPIETLET LYLSDWRPLL SISHLYSEQE NSTEETNMVD KIEVLESFAE YLQRTIDSHN
TVKPLMISRW RRTRNFERAM DNWNKKYLYL NELNERTSVY LNALQLAQRS VKH
