ID   CB5D1_XENTR             Reviewed;         217 AA.
AC   Q0IHR1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Cytochrome b5 domain-containing protein 1;
GN   Name=cyb5d1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
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DR   EMBL; BC123012; AAI23013.1; -; mRNA.
DR   RefSeq; NP_001072620.1; NM_001079152.1.
DR   AlphaFoldDB; Q0IHR1; -.
DR   SMR; Q0IHR1; -.
DR   STRING; 8364.ENSXETP00000058803; -.
DR   PaxDb; Q0IHR1; -.
DR   DNASU; 780076; -.
DR   Ensembl; ENSXETT00000104771; ENSXETP00000069272; ENSXETG00000034790.
DR   GeneID; 780076; -.
DR   KEGG; xtr:780076; -.
DR   CTD; 124637; -.
DR   Xenbase; XB-GENE-5897831; cyb5d1.
DR   eggNOG; KOG0537; Eukaryota.
DR   InParanoid; Q0IHR1; -.
DR   OrthoDB; 1534331at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000034790; Expressed in testis and 10 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..217
FT                   /note="Cytochrome b5 domain-containing protein 1"
FT                   /id="PRO_0000312320"
FT   DOMAIN          6..89
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         41
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         72
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
SQ   SEQUENCE   217 AA;  25126 MW;  AF2791413D433F64 CRC64;
     MSPVRPRFYT PREVSRHCIV SDLWVSYLGR VYDLSPLLEL HKGDVLLKPI IEAAGRDISH
     WFNPKTGDVK THIDPQTGCL KYYTPQGRFL HTAPSFPCSG WDNDFGRPWW KESTYQIGIL
     SSKTKFIRII NTLTSQEQAL EVCSEETIRE ILGRYLPYNG HAGSYTWKFC GLPLDMDKTL
     QENGVWDEDE EFEELKIASD LYTPSIHLYF NDDLTEL