YELA_DICDI
ID YELA_DICDI Reviewed; 909 AA.
AC Q23925; Q54VV2;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Yellow mounds protein A;
DE Short=YELA;
GN Name=yelA; Synonyms=DG1014; ORFNames=DDB_G0280047;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=AX4;
RX PubMed=9254905;
RX DOI=10.1002/(sici)1520-6408(1997)20:4<307::aid-dvg2>3.0.co;2-b;
RA Osherov N., Wang N., Loomis W.F.;
RT "Precocious sporulation and developmental lethality in yelA null mutants of
RT Dictyostelium.";
RL Dev. Genet. 20:307-319(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Plays as essential role in regulating terminal
CC differentiation. {ECO:0000269|PubMed:9254905}.
CC -!- DEVELOPMENTAL STAGE: First accumulates at 8 hours of development and is
CC maintained in both prespore and prestalk cells until culmination when
CC it is found only is stalk cells. During the mound stage, equally
CC abundant in all cells, whereas during the finger/migrating slug stage,
CC expression is somewhat higher in the anterior prestalk region. During
CC culmination predominantly seen in the descending stalk tube.
CC {ECO:0000269|PubMed:9254905}.
CC -!- DISRUPTION PHENOTYPE: Null cells are arrested at the tight mound stage
CC but accumulate the bright yellow pigment characteristic of mature sori.
CC Although these mutant strains do not form fruiting bodies, many of the
CC cells encapsulate within the mounds. Sporulation occurs about 6 hours
CC earlier, accompanied by precocious expression of a prespore gene, spiA.
CC However, the spores are defective and lose viability over a period of
CC several hours. Unencapsulated cells also die unless they are
CC dissociated from the mounds and shaken in suspension.
CC {ECO:0000269|PubMed:9254905}.
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DR EMBL; U63062; AAB04027.1; -; mRNA.
DR EMBL; AAFI02000035; EAL67250.1; -; Genomic_DNA.
DR RefSeq; XP_641253.1; XM_636161.1.
DR AlphaFoldDB; Q23925; -.
DR STRING; 44689.DDB0214918; -.
DR PaxDb; Q23925; -.
DR EnsemblProtists; EAL67250; EAL67250; DDB_G0280047.
DR GeneID; 8622385; -.
DR KEGG; ddi:DDB_G0280047; -.
DR dictyBase; DDB_G0280047; yelA.
DR eggNOG; ENOG502RA65; Eukaryota.
DR HOGENOM; CLU_319695_0_0_1; -.
DR InParanoid; Q23925; -.
DR OMA; IIDSKIW; -.
DR PRO; PR:Q23925; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IMP:dictyBase.
DR GO; GO:1903014; P:cellular response to differentiation-inducing factor 1; IMP:dictyBase.
DR GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
DR GO; GO:0031286; P:negative regulation of sorocarp stalk cell differentiation; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..909
FT /note="Yellow mounds protein A"
FT /id="PRO_0000377482"
FT DOMAIN 7..283
FT /note="MIF4G"
FT REGION 178..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 845..877
FT /evidence="ECO:0000255"
FT COMPBIAS 178..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..649
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 909 AA; 102109 MW; 132EF1BAE3CDD87F CRC64;
MSQSDPLNVV SRILNKISKD NFQVLIDQLV SKCQLLDKNE STLFINNIFE KVVEEPSSSS
YYIQIINKIQ PIFQQNFSIG VGNKLVENFN KRYQILTDQI NSNEETFDFN SSKQSFLNLC
KFMGECYYTL PSSFLVDVVN NHLPQVTKET ADDMTLQQLM EIEIIATSFT SAGKTIESMG
GFSSKHENNK THNNNNNNNN HDHDDDDHDE EDNENNYENT TSTTNNINNN NIQSRENDLH
FKGIQKALED ATSVLSFLIE NRQLLPPRVR FMVKNLFELK NNKWIIPKAI NDDLNAQREV
VKVATNHGKT ISKSLSEKCD DDSTLNTIFW KSFFQALGIQ NYKILRQLML DDKSNISPSS
TSPTIPLSPF LRRSMNITSP SQFNLNNCNN NNNSININNN NMDIDASFDL NDGLMESSSN
NNNSNSQLQF SLSSSSGIKD NHNVPTIDLN TISSNNNQQI NLPSGFLSPK VARSNSPSLS
SVVKQPQSQQ NNNNNNNNNN NNTTITTTTS SNNNINNNNN NNNNNKIKES PELSSAPDSN
LSVIVSIIDS KIWTPQKEIW KKKIMNKIIP MKSILKKPQK IEILAAIWQN MCDNNYEYGS
YLDLCLNLIK MDEGDISPLY SLDGGNVPPV KPYQQSAQPP PPPPSSSSSS AQQPPNEPVN
PLLNKLKGPN RRSSMATLQM KPSGISEARR SSISVPFELN RRGSLSGDIP SYCPPAPKLK
STPTLKSTPA IVQNGGSITS TSSSSSSSSS SSSSTTKNIH PTSESKKQPI AKKHKPDLDS
FKDVLISSLQ DDFALKMFVK KRSLTTYMEL LKDLYREFII EIPLLLKCIS LVHNGLYELT
DEECTMLFDL EEMAQEQQNL EKQNDQQQNL LTQNNQIFQW KTNTWEEKPQ TPPPPPTSYF
DLGSDVFVL
