YELL_DROME
ID YELL_DROME Reviewed; 541 AA.
AC P09957; Q9W5G5;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Protein yellow;
DE Flags: Precursor;
GN Name=y; ORFNames=CG3757;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=16052739; DOI=10.1002/j.1460-2075.1986.tb04688.x;
RA Chia W., Howes G., Martin M., Meng Y.B., Moses K., Tsubota S.;
RT "Molecular analysis of the yellow locus of Drosophila.";
RL EMBO J. 5:3597-3605(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=3096713; DOI=10.1002/j.1460-2075.1986.tb04548.x;
RA Geyer P.K., Spana C., Corces V.G.;
RT "On the molecular mechanism of gypsy-induced mutations at the yellow locus
RT of Drosophila melanogaster.";
RL EMBO J. 5:2657-2662(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
CC -!- FUNCTION: Controls the pigmentation pattern of the adult cuticle and
CC larval mouth parts. {ECO:0000269|PubMed:16052739,
CC ECO:0000269|PubMed:3096713}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: Required during the later half of pupal
CC development for the normal pigmentation of the adult cuticle.
CC -!- DISRUPTION PHENOTYPE: Flies fail to pigment the adult cuticle and
CC larval mouth parts and show reduced level of locomotor activity and
CC male competitive mating ability. {ECO:0000269|PubMed:16052739,
CC ECO:0000269|PubMed:3096713}.
CC -!- SIMILARITY: Belongs to the major royal jelly protein family.
CC {ECO:0000305}.
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DR EMBL; X04427; CAA28024.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF45497.1; -; Genomic_DNA.
DR EMBL; AL023873; CAA19640.1; -; Genomic_DNA.
DR PIR; A25696; A25696.
DR RefSeq; NP_476792.1; NM_057444.3.
DR AlphaFoldDB; P09957; -.
DR SMR; P09957; -.
DR BioGRID; 57553; 17.
DR DIP; DIP-23590N; -.
DR IntAct; P09957; 1.
DR STRING; 7227.FBpp0070070; -.
DR GlyGen; P09957; 2 sites.
DR PaxDb; P09957; -.
DR PRIDE; P09957; -.
DR EnsemblMetazoa; FBtr0070071; FBpp0070070; FBgn0004034.
DR GeneID; 30980; -.
DR KEGG; dme:Dmel_CG3757; -.
DR UCSC; CG3757-RA; d. melanogaster.
DR CTD; 30980; -.
DR FlyBase; FBgn0004034; y.
DR VEuPathDB; VectorBase:FBgn0004034; -.
DR eggNOG; ENOG502QQ50; Eukaryota.
DR GeneTree; ENSGT00530000064224; -.
DR HOGENOM; CLU_503077_0_0_1; -.
DR InParanoid; P09957; -.
DR OMA; LQERYSW; -.
DR OrthoDB; 940689at2759; -.
DR PhylomeDB; P09957; -.
DR SignaLink; P09957; -.
DR BioGRID-ORCS; 30980; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 30980; -.
DR PRO; PR:P09957; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0004034; Expressed in larva and 6 other tissues.
DR ExpressionAtlas; P09957; baseline and differential.
DR Genevisible; P09957; DM.
DR GO; GO:0070451; C:cell hair; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005576; C:extracellular region; IDA:FlyBase.
DR GO; GO:0048067; P:cuticle pigmentation; IMP:FlyBase.
DR GO; GO:0048066; P:developmental pigmentation; IMP:FlyBase.
DR GO; GO:0048065; P:male courtship behavior, veined wing extension; IMP:FlyBase.
DR GO; GO:0060179; P:male mating behavior; IMP:FlyBase.
DR GO; GO:0042438; P:melanin biosynthetic process; IMP:FlyBase.
DR GO; GO:0006583; P:melanin biosynthetic process from tyrosine; TAS:FlyBase.
DR GO; GO:0048082; P:regulation of adult chitin-containing cuticle pigmentation; IGI:FlyBase.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR017996; Royal_jelly/protein_yellow.
DR InterPro; IPR029846; Yellow.
DR PANTHER; PTHR10009; PTHR10009; 1.
DR PANTHER; PTHR10009:SF14; PTHR10009:SF14; 1.
DR Pfam; PF03022; MRJP; 1.
DR PRINTS; PR01366; ROYALJELLY.
PE 2: Evidence at transcript level;
KW Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..541
FT /note="Protein yellow"
FT /id="PRO_0000031052"
FT REGION 443..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 541 AA; 60520 MW; 7728D1FA9A4ECB7A CRC64;
MFQDKGWILV TLITLVTPSW AAYKLQERYS WSQLDFAFPN TRLKDQALAS GDYIPQNALP
VGVEHFGNRL FVTVPRWRDG IPATLTYINM DRSLTGSPEL IPYPDWRSNT AGDCANSITT
AYRIKVDECG RLWVLDTGTV GIGNTTTNPC PYAVNVFDLT TDTRIRRYEL PGVDTNPNTF
IANIAVDIGK NCDDAYAYFA DELGYGLIAY SWELNKSWRF SAHSYFFPDP LRGDFNVAGI
NFQWGEEGIF GMSLSPIRSD GYRTLYFSPL ASHRQFAVST RILRDETRTE DSYHDFVALD
ERGPNSHTTS RVMSDDGIEL FNLIDQNAVG CWHSSMPYSP QFHGIVDRDD VGLVFPADVK
IDENKNVWVL SDRMPVFLLS DLDYSDTNFR IYTAPLATLI ENTVCDLRNN AYGPPNTVSI
PKQAVLPMGP PLYTKQYRPV LPQKPQTSWA SSPPPPSRTY LPANSGNVVS SISVSTNSVG
PAGVEVPKAY IFNQHNGINY ETSGPHLFPT HQPAQPGGQD GGLKTYVNAR QSGWWHHQHQ
G
