ID   YELL_DROPS              Reviewed;         560 AA.
AC   Q9BI18; Q29HC0;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein yellow;
DE   Flags: Precursor;
GN   Name=y; ORFNames=GA17665;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11371593; DOI=10.1093/oxfordjournals.molbev.a003876;
RA   Munte A.B., Aguade M., Segarra C.;
RT   "Changes in the recombinational environment affect divergence in the yellow
RT   gene of Drosophila.";
RL   Mol. Biol. Evol. 18:1045-1056(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Controls the pigmentation pattern of the adult cuticle and
CC       larval mouth parts. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the major royal jelly protein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ300666; CAC34737.1; -; Genomic_DNA.
DR   EMBL; CH379064; EAL31838.2; -; Genomic_DNA.
DR   RefSeq; XP_001354783.2; XM_001354747.3.
DR   AlphaFoldDB; Q9BI18; -.
DR   SMR; Q9BI18; -.
DR   STRING; 7237.FBpp0288022; -.
DR   PRIDE; Q9BI18; -.
DR   EnsemblMetazoa; FBtr0289584; FBpp0288022; FBgn0013863.
DR   GeneID; 4815371; -.
DR   KEGG; dpo:Dpse_GA17665; -.
DR   eggNOG; ENOG502QQ50; Eukaryota.
DR   HOGENOM; CLU_031076_2_0_1; -.
DR   InParanoid; Q9BI18; -.
DR   OMA; LQERYSW; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0013863; Expressed in adult organism.
DR   GO; GO:0070451; C:cell hair; IEA:EnsemblMetazoa.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048067; P:cuticle pigmentation; IEA:EnsemblMetazoa.
DR   GO; GO:0048065; P:male courtship behavior, veined wing extension; IEA:EnsemblMetazoa.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:EnsemblMetazoa.
DR   GO; GO:0048082; P:regulation of adult chitin-containing cuticle pigmentation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.120.10.30; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR017996; Royal_jelly/protein_yellow.
DR   InterPro; IPR029846; Yellow.
DR   PANTHER; PTHR10009; PTHR10009; 1.
DR   PANTHER; PTHR10009:SF14; PTHR10009:SF14; 1.
DR   Pfam; PF03022; MRJP; 1.
DR   PRINTS; PR01366; ROYALJELLY.
PE   3: Inferred from homology;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..560
FT                   /note="Protein yellow"
FT                   /id="PRO_0000031053"
FT   REGION          452..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        224
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        11
FT                   /note="A -> L (in Ref. 1; CAC34737)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   560 AA;  61850 MW;  A1072876F4383616 CRC64;
     MHVQDKGGIG ALTALSLLLV AVTMVTPTQA AYKLQERYSW NQLDFAFPNA RLKEQAMASG
     DYIPQNALPV GVEHFGNRLF VTVPRWRDGI PATLTYINMD HSVTGSPELI PYPDWRANTA
     GDCANSITTA YRIKVDECGR LWVLDTGTVG IGNTTTNPCP YAVNVFDLTT NTRIRRYELP
     AADTNPNTFI ANIAVDIGKN CDDAYAYFAD ELGYGLISYS WELNKSWRFS AHSYFFPDPL
     RGDFNVAGIN FQWGEEGIFG MSLTPIRSDG YRTLYFSPLA SHRQFAVSTR ILRDETRIED
     SYHDFVALDE RGPNAHTTSR VMSDDGVELF NLIDQNAVGC WHSSMPYSPQ FHGIVDRDDV
     GLVFPADVKI DENKNVWVLS DRMPVFLLSD LDYSDINFRI YTAPLATLIE NTVCDLRNNA
     YGPPNTVSIP KQVGPGPRPG LSAVGPPLYT NQYRPVLPQK PQTSWGPSPP SRSYLPSLGA
     SPGGPGQVVS SVSVSTNSVG PAGIEVPKAY VFNQHNGLNY ETSGPHLFPT LQPTQSQVGG
     GLKTYVNARQ SGWWHHQHQG