YELL_DROSU
ID YELL_DROSU Reviewed; 568 AA.
AC O02437; Q9GN26; Q9GNB8; Q9GNE1; Q9GP52; Q9GP53; Q9GP54; Q9GP55; Q9GP56;
AC Q9GP57; Q9GP58; Q9GP59;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Protein yellow;
DE Flags: Precursor;
GN Name=y;
OS Drosophila subobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7241;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9286677; DOI=10.1093/genetics/147.1.165;
RA Munte A., Aguade M., Segarra C.;
RT "Divergence of the yellow gene between Drosophila melanogaster and D.
RT subobscura: recombination rate, codon bias and synonymous substitutions.";
RL Genetics 147:165-175(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Various strains;
RX PubMed=11110911; DOI=10.1093/oxfordjournals.molbev.a026296;
RA Munte A., Aguade M., Segarra C.;
RT "Nucleotide variation at the yellow gene region is not reduced in
RT Drosophila subobscura: a study in relation to chromosomal polymorphism.";
RL Mol. Biol. Evol. 17:1942-1955(2000).
CC -!- FUNCTION: Controls the pigmentation pattern of the adult cuticle and
CC larval mouth parts. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the major royal jelly protein family.
CC {ECO:0000305}.
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DR EMBL; Y13909; CAA74207.1; -; Genomic_DNA.
DR EMBL; AJ289811; CAC16212.1; -; Genomic_DNA.
DR EMBL; AJ289787; CAC16188.1; -; Genomic_DNA.
DR EMBL; AJ289788; CAC16189.1; -; Genomic_DNA.
DR EMBL; AJ289789; CAC16190.1; -; Genomic_DNA.
DR EMBL; AJ289790; CAC16191.1; -; Genomic_DNA.
DR EMBL; AJ289791; CAC16192.1; -; Genomic_DNA.
DR EMBL; AJ289792; CAC16193.1; -; Genomic_DNA.
DR EMBL; AJ289793; CAC16194.1; -; Genomic_DNA.
DR EMBL; AJ289794; CAC16195.1; -; Genomic_DNA.
DR EMBL; AJ289795; CAC16196.1; -; Genomic_DNA.
DR EMBL; AJ289796; CAC16197.1; -; Genomic_DNA.
DR EMBL; AJ289797; CAC16198.1; -; Genomic_DNA.
DR EMBL; AJ289798; CAC16199.1; -; Genomic_DNA.
DR EMBL; AJ289799; CAC16200.1; -; Genomic_DNA.
DR EMBL; AJ289800; CAC16201.1; -; Genomic_DNA.
DR EMBL; AJ289801; CAC16202.1; -; Genomic_DNA.
DR EMBL; AJ289802; CAC16203.1; -; Genomic_DNA.
DR EMBL; AJ289803; CAC16204.1; -; Genomic_DNA.
DR EMBL; AJ289804; CAC16205.1; -; Genomic_DNA.
DR EMBL; AJ289805; CAC16206.1; -; Genomic_DNA.
DR EMBL; AJ289806; CAC16207.1; -; Genomic_DNA.
DR EMBL; AJ289807; CAC16208.1; -; Genomic_DNA.
DR EMBL; AJ289808; CAC16209.1; -; Genomic_DNA.
DR EMBL; AJ289809; CAC16210.1; -; Genomic_DNA.
DR EMBL; AJ289810; CAC16211.1; -; Genomic_DNA.
DR AlphaFoldDB; O02437; -.
DR SMR; O02437; -.
DR FlyBase; FBgn0015179; Dsub\y.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0060179; P:male mating behavior; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR017996; Royal_jelly/protein_yellow.
DR InterPro; IPR029846; Yellow.
DR PANTHER; PTHR10009; PTHR10009; 1.
DR PANTHER; PTHR10009:SF14; PTHR10009:SF14; 1.
DR Pfam; PF03022; MRJP; 1.
DR PRINTS; PR01366; ROYALJELLY.
PE 3: Inferred from homology;
KW Developmental protein; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..568
FT /note="Protein yellow"
FT /id="PRO_0000031055"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 7..8
FT /note="GG -> EE (in strain: 417RIB/A1)"
FT VARIANT 9
FT /note="I -> V (in strain: 205RIB/A2, 208RIB/A2, 209RIB/A2,
FT 211RIB/A2 and 240RIB/AST)"
FT VARIANT 155
FT /note="N -> H (in strain: 201RIB/A1)"
FT VARIANT 163
FT /note="I -> V (in strain: 200RIB/A1, 201RIB/A1, 203RIB/A1,
FT 233RIB/A1, 238RIB/AST, 332RIB/A1, 358RIB/A1, 394RIB/A1,
FT 417RIB/A1 and 441RIB/A1)"
FT VARIANT 167
FT /note="A -> T (in strain: 200RIB/A1, 201RIB/A1, 203RIB/A1,
FT 233RIB/A1, 238RIB/AST, 332RIB/A1, 358RIB/A1, 394RIB/A1,
FT 417RIB/A1 and 441RIB/A1)"
FT VARIANT 198
FT /note="S -> N (in strain: 200RIB/A1, 238RIB/AST, 358RIB/A1,
FT 340RIB/A1, 394RIB/A1 and 441RIB/A1)"
FT VARIANT 262
FT /note="T -> S (in strain: 240RIB/Ast)"
FT VARIANT 323
FT /note="D -> N (in strain: 205RIB/A2)"
FT VARIANT 451
FT /note="P -> S (in strain: 200RIB/A1, 201RIB/A1, 203RIB/A1,
FT 233RIB/A1, 332RIB/A1, 340RIB/A1, 358RIB/A1, 394RIB/A1,
FT 441RIB/A1 and 417RIB/A1)"
FT VARIANT 476
FT /note="G -> S (in strain: 206RIB/AST)"
FT VARIANT 480
FT /note="I -> V (in strain: 211RIB/A2)"
SQ SEQUENCE 568 AA; 62590 MW; 4DA51B156639177F CRC64;
MHAQDKGGIL PALSLLLIAV AMVSPSQAAY KLQERYSWNQ LDFAFPSARL KEQALASGDY
IPTNALPVGV EHFGNRLFVT VPRWRDGIPA TLTYINMDHS VTGSPELIPY PDWRANTAGD
CANSITTAYR IKVDECGRLW VLDTGTVGIG NTTTNPCPYA INIFDLATDT RIRRYELPAA
DTNPNTFIAN IAVDIGKSCD DAFAYFADEL GYGLISYSWE LNKSWRFSAH SYFFPDPLRG
DFNVAGINFQ WGEEGIFGMS LTPIRSDGYR TLYFSPLASH RQFAVSTRIL RDETRTEDSY
HDFVALDERG PNAHTTSRVM SDDGVELFNL IDQNAVGCWH SSMPYSPQSH GIVDRDDVGL
VFPADIKIDE NKNVWVLSDR MPVFLLSDLD YSDTNFRIYT APLATLIENT VCDLRNNAYG
PPNTVSIPKQ AAPGHSAVGP PLYTTTNQYR PVLSQKPQTS WGPSLPSRNY LPALNGNPGI
PGSRNNLNNL GAPGQVVSSV SVSTNTVGPS GIEVPKAYVF NQHNGLNYET SGPHLFPTLQ
PAPSQLGGGL KTYVNARQSG WWHHQQQG