ID   CB60A_ARATH             Reviewed;         494 AA.
AC   C0SVV6; F4K6J3; Q8RWH0; Q9FJI9;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Calmodulin-binding protein 60 A {ECO:0000303|PubMed:11782485};
GN   Name=CBP60A {ECO:0000303|PubMed:11782485};
GN   OrderedLocusNames=At5g62570 {ECO:0000312|Araport:AT5G62570};
GN   ORFNames=K19B1.18 {ECO:0000312|EMBL:BAB11507.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:BAH30647.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA   Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT   features of the regions of 1,013,767 bp covered by sixteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:297-308(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA   Takagi M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-494 (ISOFORM 1/2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11782485; DOI=10.1074/jbc.m111626200;
RA   Reddy V.S., Ali G.S., Reddy A.S.N.;
RT   "Genes encoding calmodulin-binding proteins in the Arabidopsis genome.";
RL   J. Biol. Chem. 277:9840-9852(2002).
CC   -!- FUNCTION: Transcription activator that binds DNA in a sequence-specific
CC       manner, likely 5'-GAAATTTTGG-3', to promote the expression of target
CC       genes. {ECO:0000250|UniProtKB:F4K2R6}.
CC   -!- SUBUNIT: Interacts with calmodulin (CaM).
CC       {ECO:0000250|UniProtKB:F4K2R6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C9T2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=C0SVV6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=C0SVV6-2; Sequence=VSP_057662;
CC   -!- TISSUE SPECIFICITY: Expressed in stems, flowers and root.
CC       {ECO:0000269|PubMed:11782485}.
CC   -!- SIMILARITY: Belongs to the plant ACBP60 protein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM91175.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB11507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB015469; BAB11507.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED97624.1; -; Genomic_DNA.
DR   EMBL; AB493809; BAH30647.1; -; mRNA.
DR   EMBL; AY128775; AAM91175.1; ALT_INIT; mRNA.
DR   EMBL; AY093097; AAM13096.1; -; mRNA.
DR   RefSeq; NP_001190597.1; NM_001203668.2. [C0SVV6-1]
DR   AlphaFoldDB; C0SVV6; -.
DR   STRING; 3702.AT5G62570.2; -.
DR   PaxDb; C0SVV6; -.
DR   PRIDE; C0SVV6; -.
DR   ProteomicsDB; 240289; -. [C0SVV6-1]
DR   DNASU; 836377; -.
DR   EnsemblPlants; AT5G62570.2; AT5G62570.2; AT5G62570. [C0SVV6-1]
DR   GeneID; 836377; -.
DR   Gramene; AT5G62570.2; AT5G62570.2; AT5G62570. [C0SVV6-1]
DR   KEGG; ath:AT5G62570; -.
DR   Araport; AT5G62570; -.
DR   TAIR; locus:2154134; AT5G62570.
DR   eggNOG; ENOG502QRWC; Eukaryota.
DR   InParanoid; C0SVV6; -.
DR   PRO; PR:C0SVV6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; C0SVV6; baseline and differential.
DR   Genevisible; C0SVV6; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IDA:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1900425; P:negative regulation of defense response to bacterium; IMP:TAIR.
DR   GO; GO:0080142; P:regulation of salicylic acid biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR012416; CBP60.
DR   PANTHER; PTHR31713; PTHR31713; 1.
DR   Pfam; PF07887; Calmodulin_bind; 1.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; Calmodulin-binding; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..494
FT                   /note="Calmodulin-binding protein 60 A"
FT                   /id="PRO_0000433045"
FT   REGION          1..62
FT                   /note="Calmodulin-binding"
FT                   /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT   REGION          132..252
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT   VAR_SEQ         1..18
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_057662"
FT   CONFLICT        239
FT                   /note="G -> V (in Ref. 4; AAM13096/AAM91175)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        247
FT                   /note="R -> L (in Ref. 4; AAM13096/AAM91175)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   494 AA;  55621 MW;  602679E67218F9C0 CRC64;
     MRIPTYDFGS KFSVVQEVMR LQTVKHFLEP VLEPLIRKVV KEEVELALGK HLAGIKWICE
     KETHPLESRN LQLKFLNNLS LPVFTSARIE GDEGQAIRVG LIDPSTGQIF SSGPASSAKL
     EVFVVEGDFN SVSDWTDEDI RNNIVREREG KKPLLNGNVF AVLNDGIGVM DEISFTDNSS
     WTRSRKFRLG VRIVDQFDYV KIREAITESF VVRDHRGELY KKHHPPSLFD EVWRLEKIGK
     DGAFHRRLNL SNINTVKDFL THFHLNSSKL RQVLGTGMSS KMWEITLDHA RSCVLDSSVH
     VYQAPGFQKK TAVVFNVVAQ VLGLLVDFQY IPAEKLSEIE KAQAEVMVID ALSHLNEVIS
     YDDEVSMMRN VLNAPASQGS VAGIDYSGLS LTSLDGYGFV SSLHNTAECS GKHSDDVDME
     VTPHGLYEDY DNLWNCSHIL GLEEPQSELQ SALDDFMSQK NASVGGKAHS KRWTKLFSVS
     RWLSVFKYVK LGKI