CB60B_ARATH
ID CB60B_ARATH Reviewed; 647 AA.
AC Q9FKL6;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Calmodulin-binding protein 60 B {ECO:0000303|PubMed:11782485};
GN Name=CBP60B {ECO:0000303|PubMed:11782485};
GN OrderedLocusNames=At5g57580 {ECO:0000312|Araport:AT5G57580};
GN ORFNames=MUA2.16 {ECO:0000312|EMBL:BAB08793.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11782485; DOI=10.1074/jbc.m111626200;
RA Reddy V.S., Ali G.S., Reddy A.S.N.;
RT "Genes encoding calmodulin-binding proteins in the Arabidopsis genome.";
RL J. Biol. Chem. 277:9840-9852(2002).
CC -!- FUNCTION: Transcription activator that binds DNA in a sequence-specific
CC manner, likely 5'-GAAATTTTGG-3', to promote the expression of target
CC genes. {ECO:0000250|UniProtKB:F4K2R6}.
CC -!- SUBUNIT: Interacts with calmodulin (CaM).
CC {ECO:0000250|UniProtKB:F4K2R6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C9T2}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems, flowers, developing
CC seeds and root. {ECO:0000269|PubMed:11782485}.
CC -!- SIMILARITY: Belongs to the plant ACBP60 protein family. {ECO:0000305}.
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DR EMBL; AB011482; BAB08793.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96923.1; -; Genomic_DNA.
DR EMBL; AY056289; AAL07138.1; -; mRNA.
DR EMBL; AY091434; AAM14373.1; -; mRNA.
DR RefSeq; NP_200566.1; NM_125139.3.
DR AlphaFoldDB; Q9FKL6; -.
DR STRING; 3702.AT5G57580.1; -.
DR iPTMnet; Q9FKL6; -.
DR PaxDb; Q9FKL6; -.
DR PRIDE; Q9FKL6; -.
DR ProteomicsDB; 223927; -.
DR EnsemblPlants; AT5G57580.1; AT5G57580.1; AT5G57580.
DR GeneID; 835862; -.
DR Gramene; AT5G57580.1; AT5G57580.1; AT5G57580.
DR KEGG; ath:AT5G57580; -.
DR Araport; AT5G57580; -.
DR TAIR; locus:2174522; AT5G57580.
DR eggNOG; ENOG502QQ42; Eukaryota.
DR HOGENOM; CLU_031504_3_0_1; -.
DR InParanoid; Q9FKL6; -.
DR OMA; QSPMPNF; -.
DR OrthoDB; 347274at2759; -.
DR PhylomeDB; Q9FKL6; -.
DR PRO; PR:Q9FKL6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKL6; baseline and differential.
DR Genevisible; Q9FKL6; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0080142; P:regulation of salicylic acid biosynthetic process; IBA:GO_Central.
DR InterPro; IPR012416; CBP60.
DR PANTHER; PTHR31713; PTHR31713; 1.
DR Pfam; PF07887; Calmodulin_bind; 1.
PE 2: Evidence at transcript level;
KW Activator; Calmodulin-binding; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..647
FT /note="Calmodulin-binding protein 60 B"
FT /id="PRO_0000433046"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8..85
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT REGION 155..278
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT MOTIF 12..19
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
SQ SEQUENCE 647 AA; 72364 MW; 1604F588CBBE2E0E CRC64;
MMDSGNNNMN RAKRNLDGND DDQPERKRPA FASVIVEALK VDSLQKLCSS LEPILRRVVS
EELERALAKL GPARLTGSSG SSPKRIEGPD GRKLQLHFKS RLSLPLFTGG KVEGEQGAVI
HVVLIDANTG RAVVYGPEAS AKLHIVVLEG DFNTEDDEDW TQEEFESHVV KERSGKRPLL
TGEVYVTLKE GVGTLGELVF TDNSSWIRSR KFRLGLRVVS GCCDGMRIRE AKTEAFVVKD
HRGELYKKHY PPALNDDVWR LDKIGKDGAF HKKLTAEGIN TVEDFLRVMV KDSPKLRTIL
GSGMSNKMWD ALVEHAKTCV QSSKLYIYYA EDSRNVGVVF NNIYELSGLI SGDQYFSADS
LTDSQKVYVE GLVKKAYENW NLVIEYDGKS LLDLKQPQRL SITHTNLENY STAAIDHPMQ
MVAGHSSSMP PNQSPVLSDF AIGGYDQTLA TRYHSHPQLL NSNPRAQFEV ASCSTSQDQF
MGNLHQTQST INNQHMNGLA LGPSQSSTSG YQNINPSSVH QADLNHLEDW SNPRERGPDD
FFSEEEIRLR SHEMLESEDM QQFLRLFSMG GGGNGSATHL PEDGYTFPSF LHTPMQGYDE
DRGRSGRAVV GWLKIKAAMR WGFFIRRKAA ERRAQIVELD DDDEDGE
