ID   YENI_YEREN              Reviewed;         214 AA.
AC   P52988;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein YenI;
GN   Name=yenI;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCTC 10460;
RX   PubMed=7494483; DOI=10.1111/j.1365-2958.1995.mmi_17020345.x;
RA   Throup J.P., Camara M., Briggs G.S., Winson M.K., Chhabra S.R.,
RA   Bycroft B.W., Williams P., Stewart G.S.A.B.;
RT   "Characterisation of the yenI/yenR locus from Yersinia enterocolitica
RT   mediating the synthesis of two N-acylhomoserine lactone signal molecules.";
RL   Mol. Microbiol. 17:345-356(1995).
CC   -!- FUNCTION: Required for the synthesis of autoinducer molecules such as
CC       OHHL (N-(3-oxohexanoyl)-L-homoserine lactone), and HHL (N-hexanoyl-L-
CC       homoserine lactone).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; X76082; CAA53693.1; -; Genomic_DNA.
DR   PIR; S70175; S70175.
DR   AlphaFoldDB; P52988; -.
DR   SMR; P52988; -.
DR   STRING; 1443113.LC20_03387; -.
DR   eggNOG; COG3916; Bacteria.
DR   PHI-base; PHI:4213; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..214
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210902"
SQ   SEQUENCE   214 AA;  24601 MW;  A7B71072548B37CE CRC64;
     MLKLFNVNFN NMPERKLDEI FSLREITFKD RLDWKVTCID GKESDQYDDE NTNYILGTID
     DTIVCSVRFI DMKYPTMITG PFAPYFSDVS LPIDGFIESS RFFVEKALAR DMVGNNSSLS
     TILFLAMVNY ARDRGHKGIL TVVSRGMFIL LKRSGWNITV LNQGESEKNE VIYLLHLGID
     NDSQQQLINK ILRVHQVEPK TLETWPIIVP GIIK