YEO3_SCHPO
ID YEO3_SCHPO Reviewed; 635 AA.
AC O13781;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Uncharacterized protein C17G6.03;
GN ORFNames=SPAC17G6.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the 5'-nucleotidase family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16214.1; -; Genomic_DNA.
DR PIR; T37835; T37835.
DR RefSeq; NP_594250.1; NM_001019673.2.
DR AlphaFoldDB; O13781; -.
DR SMR; O13781; -.
DR BioGRID; 278757; 11.
DR STRING; 4896.SPAC17G6.03.1; -.
DR PaxDb; O13781; -.
DR EnsemblFungi; SPAC17G6.03.1; SPAC17G6.03.1:pep; SPAC17G6.03.
DR GeneID; 2542289; -.
DR KEGG; spo:SPAC17G6.03; -.
DR PomBase; SPAC17G6.03; -.
DR VEuPathDB; FungiDB:SPAC17G6.03; -.
DR eggNOG; KOG4419; Eukaryota.
DR HOGENOM; CLU_019028_0_0_1; -.
DR InParanoid; O13781; -.
DR OMA; NEIMGLY; -.
DR PhylomeDB; O13781; -.
DR PRO; PR:O13781; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0008253; F:5'-nucleotidase activity; ISO:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046085; P:adenosine metabolic process; ISO:PomBase.
DR GO; GO:0034655; P:nucleobase-containing compound catabolic process; IC:PomBase.
DR GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR CDD; cd07407; MPP_YHR202W_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.90.780.10; -; 1.
DR InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR InterPro; IPR006179; 5_nucleotidase/apyrase.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR014485; Pesterase_C1039.
DR InterPro; IPR041823; YHR202W_N.
DR PANTHER; PTHR11575; PTHR11575; 1.
DR PANTHER; PTHR11575:SF22; PTHR11575:SF22; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PIRSF; PIRSF017316; Pesterase_C1039; 1.
DR SUPFAM; SSF55816; SSF55816; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
DR PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..635
FT /note="Uncharacterized protein C17G6.03"
FT /id="PRO_0000310953"
FT BINDING 45
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 47
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 125
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 260
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 467
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT SITE 126
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250"
SQ SEQUENCE 635 AA; 71442 MW; DF9517858D8EA9A0 CRC64;
MKPAHTFSLI FSLLFVINPC YSATLPLAIR RELTWGQVNI LHTTDIHGWL AGHARDKRYS
GDLGDFASFV QHMKHLAKQK DVDLLLVDTG DLHDGTGLSD LTDPPGSWTD SLLANMDYDI
LVAGNHELYL STVANDTYHN FIPLWEGRYL AANIDIYDEH VSSFVPFGDR YAIFSTPHNV
KILAFGFVNS FSGATDTVRV LPVSQFSLQP WWNDMVSNKD IDLILIPAHV PVHNASELDI
VLSELRIHFP TTPIQVLGGH SHIRDYAIYD EKAVGIESGR YCETVGWVSI NGIPSFKSLV
KLSGISSLMG VESYLAERLR FIGESIRRSS QQIFSSLQSA KSASVSFSRS YIDWNPEGFM
FHSKTKKSSF NTSLGEFISN GIYEARKALG LLTPIGCSPK KFAFSEVPFN DSNSIYHLFQ
SELFPKIVVN ESRHHIPHYI IVNSGGIRGG LNSGAFGLDE VFQVCPFKSN IFYVLKDVPW
SITKYLPQAL QHSGYLIAED TLQINTPQVS DAKFEDFYEH SIRKTYGYTT HDDLGDDGDD
TAHLTTPHYE PLRFICSQVG FDDSFSGDDK QVVDVVAPSF VIPRLDDILN KIADKPLYSP
DDWELYFTRP DGKHSMTDLL PLYADLYWDH DCLYK
