YERA_YERPE
ID YERA_YERPE Reviewed; 130 AA.
AC P31491;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=YopE regulator;
GN Name=yerA; OrderedLocusNames=YPCD1.05c, y5069, y0078, YP_pCD82;
OS Yersinia pestis.
OG Plasmid pCD1, and Plasmid pYV019.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EV 76; PLASMID=pYV019;
RX PubMed=2307658; DOI=10.1128/jb.172.3.1547-1555.1990;
RA Forsberg A., Wolf-Watz H.;
RT "Genetic analysis of the yopE region of Yersinia spp.: identification of a
RT novel conserved locus, yerA, regulating yopE expression.";
RL J. Bacteriol. 172:1547-1555(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis; PLASMID=pCD1;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis; PLASMID=pCD1;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis; PLASMID=pCD1;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis; PLASMID=pCD1;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Positive regulator of YopE.
CC -!- INTERACTION:
CC P31491; Q04206: RELA; Xeno; NbExp=2; IntAct=EBI-2840013, EBI-73886;
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DR EMBL; M34279; AAA27671.1; -; Genomic_DNA.
DR EMBL; AF074612; AAC69819.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62588.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54882.1; -; Genomic_DNA.
DR EMBL; AE017043; AAS58593.1; -; Genomic_DNA.
DR PIR; T43606; T43606.
DR RefSeq; NP_395142.1; NC_003131.1.
DR RefSeq; NP_857763.1; NC_004836.1.
DR RefSeq; NP_857968.1; NC_004839.1.
DR RefSeq; WP_002213403.1; NZ_WUCM01000133.1.
DR PDB; 1JYA; X-ray; 1.74 A; A/B=1-130.
DR PDB; 1K6Z; X-ray; 2.00 A; A/B=1-130.
DR PDBsum; 1JYA; -.
DR PDBsum; 1K6Z; -.
DR AlphaFoldDB; P31491; -.
DR BMRB; P31491; -.
DR SMR; P31491; -.
DR IntAct; P31491; 5.
DR MINT; P31491; -.
DR STRING; 214092.5832428; -.
DR DrugBank; DB03366; Imidazole.
DR DNASU; 1149333; -.
DR EnsemblBacteria; AAS58593; AAS58593; YP_pCD82.
DR GeneID; 66841064; -.
DR KEGG; ype:YPCD1.05c; -.
DR KEGG; ypm:YP_pCD82; -.
DR PATRIC; fig|214092.21.peg.6; -.
DR eggNOG; ENOG50332A3; Bacteria.
DR HOGENOM; CLU_159406_0_0_6; -.
DR OMA; LFSQDPC; -.
DR EvolutionaryTrace; P31491; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR Proteomes; UP000001019; Plasmid pCD1.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR InterPro; IPR005416; T3SS_chp_SycE.
DR InterPro; IPR010261; Tir_chaperone.
DR Pfam; PF05932; CesT; 1.
DR PIRSF; PIRSF011271; T3SS_chp_SycE_GmN_bac; 1.
DR PRINTS; PR01596; SYCECHAPRONE.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Plasmid; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..130
FT /note="YopE regulator"
FT /id="PRO_0000066203"
FT HELIX 4..15
FT /evidence="ECO:0007829|PDB:1K6Z"
FT STRAND 25..31
FT /evidence="ECO:0007829|PDB:1K6Z"
FT STRAND 34..40
FT /evidence="ECO:0007829|PDB:1K6Z"
FT STRAND 45..50
FT /evidence="ECO:0007829|PDB:1K6Z"
FT HELIX 60..65
FT /evidence="ECO:0007829|PDB:1K6Z"
FT STRAND 77..81
FT /evidence="ECO:0007829|PDB:1K6Z"
FT TURN 82..85
FT /evidence="ECO:0007829|PDB:1K6Z"
FT STRAND 86..94
FT /evidence="ECO:0007829|PDB:1K6Z"
FT HELIX 95..97
FT /evidence="ECO:0007829|PDB:1K6Z"
FT HELIX 102..116
FT /evidence="ECO:0007829|PDB:1K6Z"
SQ SEQUENCE 130 AA; 14650 MW; 41A12BB29831CA5A CRC64;
MYSFEQAITQ LFQQLSLSIP DTIEPVIGVK VGEFACHITE HPVGQILMFT LPSLDNNDEK
ETLLSHNIFS QDILKPILSW DEVGGHPVLW NRQPLNSLDN NSLYTQLEML VQGAERLQTS
SLISPPRSFS
