CB60C_ARATH
ID CB60C_ARATH Reviewed; 622 AA.
AC C0SV51; Q944Q2; Q9ZV44;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Calmodulin-binding protein 60 C {ECO:0000303|PubMed:11782485};
GN Name=CBP60C {ECO:0000303|PubMed:11782485};
GN OrderedLocusNames=At2g18750 {ECO:0000312|Araport:AT2G18750};
GN ORFNames=MSF3.13 {ECO:0000312|EMBL:AAD08944.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAH30392.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11782485; DOI=10.1074/jbc.m111626200;
RA Reddy V.S., Ali G.S., Reddy A.S.N.;
RT "Genes encoding calmodulin-binding proteins in the Arabidopsis genome.";
RL J. Biol. Chem. 277:9840-9852(2002).
CC -!- FUNCTION: Transcription activator that binds DNA in a sequence-specific
CC manner, likely 5'-GAAATTTTGG-3', to promote the expression of target
CC genes. {ECO:0000250|UniProtKB:F4K2R6}.
CC -!- SUBUNIT: Interacts with calmodulin (CaM).
CC {ECO:0000250|UniProtKB:F4K2R6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C9T2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=C0SV51-1; Sequence=Displayed;
CC Name=2;
CC IsoId=C0SV51-2; Sequence=VSP_057663;
CC -!- TISSUE SPECIFICITY: Expressed in stems, flowers and root.
CC {ECO:0000269|PubMed:11782485}.
CC -!- SIMILARITY: Belongs to the plant ACBP60 protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD08944.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005724; AAD08944.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06802.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06803.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06804.1; -; Genomic_DNA.
DR EMBL; AF424622; AAL11615.1; -; mRNA.
DR EMBL; AY143850; AAN28789.1; -; mRNA.
DR EMBL; AB493554; BAH30392.1; -; mRNA.
DR PIR; B84568; B84568.
DR RefSeq; NP_001031372.1; NM_001036295.2. [C0SV51-1]
DR RefSeq; NP_001189550.1; NM_001202621.2. [C0SV51-1]
DR RefSeq; NP_565441.2; NM_127431.3. [C0SV51-1]
DR AlphaFoldDB; C0SV51; -.
DR STRING; 3702.AT2G18750.3; -.
DR iPTMnet; C0SV51; -.
DR PaxDb; C0SV51; -.
DR PRIDE; C0SV51; -.
DR ProteomicsDB; 222787; -. [C0SV51-1]
DR EnsemblPlants; AT2G18750.1; AT2G18750.1; AT2G18750. [C0SV51-1]
DR EnsemblPlants; AT2G18750.2; AT2G18750.2; AT2G18750. [C0SV51-1]
DR EnsemblPlants; AT2G18750.3; AT2G18750.3; AT2G18750. [C0SV51-1]
DR GeneID; 816390; -.
DR Gramene; AT2G18750.1; AT2G18750.1; AT2G18750. [C0SV51-1]
DR Gramene; AT2G18750.2; AT2G18750.2; AT2G18750. [C0SV51-1]
DR Gramene; AT2G18750.3; AT2G18750.3; AT2G18750. [C0SV51-1]
DR KEGG; ath:AT2G18750; -.
DR Araport; AT2G18750; -.
DR TAIR; locus:2054000; AT2G18750.
DR eggNOG; ENOG502QQ42; Eukaryota.
DR HOGENOM; CLU_031504_3_0_1; -.
DR InParanoid; C0SV51; -.
DR OMA; TTQYERS; -.
DR PhylomeDB; C0SV51; -.
DR PRO; PR:C0SV51; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; C0SV51; baseline and differential.
DR Genevisible; C0SV51; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0080142; P:regulation of salicylic acid biosynthetic process; IBA:GO_Central.
DR InterPro; IPR012416; CBP60.
DR PANTHER; PTHR31713; PTHR31713; 1.
DR Pfam; PF07887; Calmodulin_bind; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Calmodulin-binding; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..622
FT /note="Calmodulin-binding protein 60 C"
FT /id="PRO_0000433047"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10..89
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT REGION 159..282
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..307
FT /note="Missing (in isoform 2)"
FT /id="VSP_057663"
SQ SEQUENCE 622 AA; 70200 MW; 011DFD90AC963F6B CRC64;
MQTRYMERTN SMREKRKLEE DDNQQQQQQP ERKRPALASV IVEALKMDSL QRLCSSLEPI
LRRVVSEEVE RALAKLGPAR LSERSSPKRI EGIGGRNLQL QFRSRLSVPL FTGGKIEGEQ
GAAIHVVLLD MTTGHVLTVG PEASAKLDVV VLDGDFNTED DDGWSGEEFE GHLVKERQGK
RPLLTGDVQV TLKEGVGTLG ELIFTDNSSW IRCRKFRLGL RVSSGYCEGM RVREAKTEAF
TVKDHRGELY KKHYPPALDD EVWRLEKIGK DGAFHKKLNK AGIYNVKEFL RLMVKDSQKL
RTILGSGMSN RMWETLAEHS KTCVLSEMLY VYYPEDSVGV VFNNIYEFSG LISGKQYYPA
DSLSDNQKGY VDGLVRKAYE NWEQVIEYDS KSLMNFNQVS KTDDIDYSMP VSVPSQPSTS
YSDVTVEAYN QSPASSFPGQ SQLADTTYMH FGNSSFAPQD QLVNNTHESQ SMINSNGGVR
LALGPATGSQ NQEQLVHPPP EINSYNDWSN TCNRGVDGFL SEEEIRARSN EMLENDDMQQ
LLRLFSMNGG DQQTPLNMGE DSFGFHSFGQ TSMADYEEDR SNSGKAVVGW LKIKAAMRWG
FFIRRKAAQR RAQIVQLDED DE
