CB60D_ARATH
ID CB60D_ARATH Reviewed; 601 AA.
AC Q0WVV6; Q9SW03;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Calmodulin-binding protein 60 D {ECO:0000303|PubMed:11782485};
GN Name=CBP60D {ECO:0000303|PubMed:11782485};
GN OrderedLocusNames=At4g25800 {ECO:0000312|Araport:AT4G25800};
GN ORFNames=F14M19.80 {ECO:0000312|EMBL:CAB39601.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAE98742.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11782485; DOI=10.1074/jbc.m111626200;
RA Reddy V.S., Ali G.S., Reddy A.S.N.;
RT "Genes encoding calmodulin-binding proteins in the Arabidopsis genome.";
RL J. Biol. Chem. 277:9840-9852(2002).
CC -!- FUNCTION: Transcription activator that binds DNA in a sequence-specific
CC manner, likely 5'-GAAATTTTGG-3', to promote the expression of target
CC genes. {ECO:0000250|UniProtKB:F4K2R6}.
CC -!- SUBUNIT: Interacts with calmodulin (CaM).
CC {ECO:0000250|UniProtKB:F4K2R6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C9T2}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems, flowers and root.
CC {ECO:0000269|PubMed:11782485}.
CC -!- SIMILARITY: Belongs to the plant ACBP60 protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB39601.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79435.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049480; CAB39601.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161564; CAB79435.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85115.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85116.1; -; Genomic_DNA.
DR EMBL; AK226631; BAE98742.1; -; mRNA.
DR PIR; T04234; T04234.
DR RefSeq; NP_001078448.1; NM_001084979.1.
DR RefSeq; NP_194310.3; NM_118712.6.
DR AlphaFoldDB; Q0WVV6; -.
DR STRING; 3702.AT4G25800.1; -.
DR iPTMnet; Q0WVV6; -.
DR PaxDb; Q0WVV6; -.
DR PRIDE; Q0WVV6; -.
DR ProteomicsDB; 239127; -.
DR EnsemblPlants; AT4G25800.1; AT4G25800.1; AT4G25800.
DR EnsemblPlants; AT4G25800.2; AT4G25800.2; AT4G25800.
DR GeneID; 828685; -.
DR Gramene; AT4G25800.1; AT4G25800.1; AT4G25800.
DR Gramene; AT4G25800.2; AT4G25800.2; AT4G25800.
DR KEGG; ath:AT4G25800; -.
DR Araport; AT4G25800; -.
DR TAIR; locus:2117557; AT4G25800.
DR eggNOG; ENOG502QQ42; Eukaryota.
DR HOGENOM; CLU_031504_3_0_1; -.
DR InParanoid; Q0WVV6; -.
DR OMA; NELTHHC; -.
DR OrthoDB; 347274at2759; -.
DR PhylomeDB; Q0WVV6; -.
DR PRO; PR:Q0WVV6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q0WVV6; baseline and differential.
DR Genevisible; Q0WVV6; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0080142; P:regulation of salicylic acid biosynthetic process; IBA:GO_Central.
DR InterPro; IPR012416; CBP60.
DR PANTHER; PTHR31713; PTHR31713; 1.
DR Pfam; PF07887; Calmodulin_bind; 1.
PE 2: Evidence at transcript level;
KW Activator; Calmodulin-binding; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..601
FT /note="Calmodulin-binding protein 60 D"
FT /id="PRO_0000433048"
FT REGION 1..74
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT REGION 144..267
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:F4K2R6"
FT MOTIF 1..8
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
SQ SEQUENCE 601 AA; 67591 MW; FB54D06661F63593 CRC64;
MKRNFERNDD DKPERKRPAL ASVIVEALKV DSLQKLCSSL EPILRRVVSE EVERALAKLV
PTRLTTSSVF SPKRIGGPDG RNLQLHFKSR LSLPLFTGGR VEGEQGATIH VVLIDANTGR
PVTVGPEASL KLEVVVLGGD FNNEDDEDWT QEEFESHVVK EREGKRPLLT GDLFVVLKEG
VGTLGEIVFT DNSSWIRSRK FRLGLRVPSG YCDGIRIREA KTEAFSVKDH RGELYKKHYP
PALNDEVWRL EKIGKDGAFH KRLTAAGIVT VEGFLRQLVR DSTKLRAILG SGMSNKMWDL
LVEHAKTCVL SGKLYIYYTE DSRSVGVVFN NIYELSGLIT EDQYLSADSL SESQKVYVDG
LVKKAYENWN QVVEYEGESL LNLNQPERLD ISQTDPVTAL ASYSTVPLSQ FPEFAIEGYN
QTLTTALPHN PQAQFDFVPQ QDQFIGIQQP QTQTNIENEN VTRLVLGPPQ SSTGGYQDIK
SSADQENLNP FEDWTNLSEN DFFSEEEIRQ TSHDLLANED MQQLLFSMGG GKGEDGFTFP
SFMQNTPMMQ GYDEEGRGRS GKAVVGWLKV KAAMRWGFFI RRKAAERRAQ IVELHDNNDG
K
