ID   YF38_SCHPO              Reviewed;         570 AA.
AC   O13899;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c;
GN   ORFNames=SPAC22A12.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16578.1; -; Genomic_DNA.
DR   PIR; T38148; T38148.
DR   RefSeq; NP_593238.1; NM_001018635.2.
DR   AlphaFoldDB; O13899; -.
DR   SMR; O13899; -.
DR   STRING; 4896.SPAC22A12.08c.1; -.
DR   iPTMnet; O13899; -.
DR   MaxQB; O13899; -.
DR   PaxDb; O13899; -.
DR   EnsemblFungi; SPAC22A12.08c.1; SPAC22A12.08c.1:pep; SPAC22A12.08c.
DR   GeneID; 2541442; -.
DR   KEGG; spo:SPAC22A12.08c; -.
DR   PomBase; SPAC22A12.08c; -.
DR   VEuPathDB; FungiDB:SPAC22A12.08c; -.
DR   eggNOG; KOG1617; Eukaryota.
DR   eggNOG; KOG1618; Eukaryota.
DR   HOGENOM; CLU_458674_0_0_1; -.
DR   InParanoid; O13899; -.
DR   OMA; FCQSHTP; -.
DR   PhylomeDB; O13899; -.
DR   Reactome; R-SPO-1482925; Acyl chain remodelling of PG.
DR   Reactome; R-SPO-1483076; Synthesis of CL.
DR   PRO; PR:O13899; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR   GO; GO:0008808; F:cardiolipin synthase activity; ISO:PomBase.
DR   GO; GO:0043337; F:CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity; IMP:PomBase.
DR   GO; GO:0016787; F:hydrolase activity; ISM:PomBase.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IMP:PomBase.
DR   GO; GO:0046474; P:glycerophospholipid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0007006; P:mitochondrial membrane organization; ISO:PomBase.
DR   GO; GO:0055091; P:phospholipid homeostasis; IMP:PomBase.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR006353; HAD-SF_hydro_IIA_CECR5.
DR   InterPro; IPR023214; HAD_sf.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01456; CECR5; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome; Transferase.
FT   CHAIN           1..570
FT                   /note="Uncharacterized CDP-alcohol phosphatidyltransferase
FT                   class-I family protein C22A12.08c"
FT                   /id="PRO_0000318105"
SQ   SEQUENCE   570 AA;  63880 MW;  7CE82DCEC2289480 CRC64;
     MLHTINYRSW HLAARQLGRS TFRKFTTESS TKSPIADVCF AFDSIDGVLI RGGRGLKEGT
     KTLKFLQKNN IPFILLTNGG GMHESVRAQR LSKTLSVSLT EDDFCQSHTP FRALADKYKH
     VLVLGGKDNS VRETAEKYGF KSVINELDVI AKLGTPFWPF TSFNEEDIKD AKDFDVTRPI
     EAVFTYVDPV RLGLDLQLVM ELGQSKNGVL GTVSKTANEG PDIYFSNADL IWPNEYPLPR
     LGQGAFAICC ESVFKELTGK DLRNTKYGKP HKLTYDYAKN ILMKKHKTLG ITNPPKEIFM
     VGDNPESDIR GANNYGWTSI LVRTGIFQGD NSPKYSAKHV SDNVWEGVRW ALSKHVPAAK
     LNKSMGEVRG FHTSSRVLNT VTKSNNSKPI QRPLRENIFT LPNLLTFSRL LSAPLIAYLY
     IYDYTKAAAC FFLYAGFTDL VDGYIARKFD LGSIAGTVLD PLADKTLMTC LTICLAVRET
     MPLTLASLII GRDVLLVSAV SYLRYKSLPA PKTFRRFFDF AIPTTELKPT RISKVCRNGL
     LSTDLCKQLV EYSFTTAVTR TFDYRAHTSF